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AB233531

Anti-Tmem27 antibody

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(1 Publication)

Rabbit Polyclonal Tmem27 antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Rat Cltrn aa 1-150.

View Alternative Names

Nx17, Tmem27, Cltrn, Collectrin, Transmembrane protein 27

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tmem27 antibody (AB233531)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tmem27 antibody (AB233531)

Formalin-fixed, paraffin-embedded rat kidney tissue stained for Tmem27 using ab233531 at 20μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-Tmem27 antibody (AB233531)
  • WB

Supplier Data

Western blot - Anti-Tmem27 antibody (AB233531)

All lanes:

Western blot - Anti-Tmem27 antibody (ab233531) at 2 µg/mL

All lanes:

Rat serum

Predicted band size: 25 kDa

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Western blot - Anti-Tmem27 antibody (AB233531)
  • WB

Supplier Data

Western blot - Anti-Tmem27 antibody (AB233531)

All lanes:

Western blot - Anti-Tmem27 antibody (ab233531) at 2 µg/mL

All lanes:

Recombinant rat Tmem27 protein

Predicted band size: 25 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Rat Cltrn aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q9ESG3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tmem27 also known as collectrin is a type I transmembrane protein with a mass of approximately 46 kDa. It is predominantly expressed in the kidney and pancreas where it localizes mostly at the apical membranes of epithelial cells in renal proximal tubules and pancreatic ducts. Tmem27 engages in processes associated with cell surface expression influencing the behavior of nearby ion channels and transporters.
Biological function summary

The involvement of Tmem27 extends to the regulation of amino acid transport and insulin exocytosis. It associates with the γ-aminobutyric acid type B receptor (GABBR) complex contributing to the modulation of nutrient uptake. Tmem27 influences the processing and trafficking of small neutral amino acids enhancing their absorption across epithelial barriers which is important for maintaining cellular homeostasis and metabolic activities.

Pathways

The function of Tmem27 is significant in the renin-angiotensin system and the insulin signaling pathway. In the renin-angiotensin system Tmem27 operates alongside the angiotensin-converting enzyme (ACE) to precisely regulate blood pressure homeostasis. It also acts within the insulin signaling pathway by modulating insulin secretion potentially working closely with glucose transporter type 4 (GLUT4) to ensure efficient glucose uptake by cells.

Tmem27 has connections to conditions such as diabetes mellitus and kidney disease. Its involvement in insulin secretion links it to diabetes impacting glucose homeostasis when irregularities occur. Tmem27's interactions with angiotensin-converting enzyme can affect blood pressure regulation creating implications for hypertension-related kidney disorders. Understanding these associations highlights the potential of Tmem27 as a therapeutic target in managing these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (PubMed : 16330323). Stimulator of beta cell replication (By similarity).
See full target information Cltrn
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2406026 PubMed39494721

2024

Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption.

Applications

Unspecified application

Species

Unspecified reactive species

Fan Ouyang,Yaling Li,Haoming Wang,Xiangyang Liu,Xiaoli Tan,Genyuan Xie,Junfa Zeng,Gaofeng Zeng,Qiong Luo,Hong Zhou,Siming Chen,Kai Hou,Jinren Fang,Xia Zhang,Linlin Zhou,Yukun Li,Anbo Gao
View all publications
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