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Rabbit Recombinant Monoclonal TM41B antibody. Carrier free. Suitable for WB, IP and reacts with Human samples.

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Images

Western blot - Anti-TMEM41B antibody [EPR28149-41] - BSA and Azide free (AB314764), expandable thumbnail
  • Western blot - Anti-TMEM41B antibody [EPR28149-41] - BSA and Azide free (AB314764), expandable thumbnail
  • Immunoprecipitation - Anti-TMEM41B antibody [EPR28149-41] - BSA and Azide free (AB314764), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.2 - 7.4
Constituents: 100% PBS

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIPIHC-PFlow Cyt (Intra)ICC/IF
Human
Tested
Tested
Not recommended
Not recommended
Not recommended
Mouse
Not recommended
Not recommended
Not recommended
Not recommended
Not recommended
Rat
Not recommended
Not recommended
Not recommended
Not recommended
Not recommended

Tested
Tested

Species
Human
Dilution info
-
Notes

-

Not recommended
Not recommended

Species
Mouse, Rat
Dilution info
-
Notes

-

Tested
Tested

Species
Human
Dilution info
-
Notes

-

Not recommended
Not recommended

Species
Mouse, Rat
Dilution info
-
Notes

-

Not recommended
Not recommended

Species
Human, Mouse, Rat
Dilution info
-
Notes

-

Not recommended
Not recommended

Species
Human, Mouse, Rat
Dilution info
-
Notes

-

Not recommended
Not recommended

Species
Human, Mouse, Rat
Dilution info
-
Notes

-

Associated Products

Select an associated product type

1 product for Alternative Version

Target data

Function

Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed:33850023, PubMed:33929485, PubMed:34015269). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed:33850023, PubMed:33929485, PubMed:34015269). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:30093494, PubMed:30126924, PubMed:30933966, PubMed:33850023, PubMed:33929485, PubMed:34015269, PubMed:34043740). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:33850023). Required for normal motor neuron development (By similarity). (Microbial infection) Critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus (PubMed:33338421, PubMed:33382968). Required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles (PubMed:33382968).

Alternative names

KIAA0033, TMEM41B, Transmembrane protein 41B, Protein stasimon

Recommended products

Rabbit Recombinant Monoclonal TM41B antibody. Carrier free. Suitable for WB, IP and reacts with Human samples.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Carrier free
Yes
Clone number
EPR28149-41
Purification technique
Affinity purification Protein A
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C

Notes

ab314764 is the carrier-free version of Anti-TMEM41B antibody [EPR28149-41] ab314763.

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.

This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

TMEM41B also known as Transmembrane Protein 41B is part of the ER membrane protein complex that plays a fundamental role in various cellular processes. It is a 35 kDa protein located predominantly in the endoplasmic reticulum membrane. TMEM41B shows expression in many tissues including heart brain kidney and skeletal muscle suggesting its important role across different biological systems.

Biological function summary

This protein functions in autophagy a process essential for cellular homeostasis and survival during stress conditions. TMEM41B associates with the ER-phagy complex where it is important for the regulation and expansion of autophagosomes. It works in coordination with proteins like VMP1 and ATG9A supporting the recruitment and stability of autophagosomal membranes which impacts the cell's ability to recycle and reuse cellular components.

Pathways

TMEM41B has a significant involvement in the autophagy and lipid metabolism pathways. It interacts with other proteins such as VMP1 and ATG9A mediating the lipid mobilization necessary for efficient autophagosome formation. These interactions ensure that TMEM41B plays a role in the homeostatic regulation of lipids and proteins contributing to proper cellular function and response to metabolic demands.

Associated diseases and disorders

TMEM41B associates with conditions like neurodegeneration and certain viral infections. Alterations or deficiencies in TMEM41B can impact its autophagic function potentially leading to neurodegenerative diseases where protein aggregates accumulate as seen in relation to ATG9A dysfunction. Additionally studies link TMEM41B to the flavivirus life cycle suggesting its necessity in viral replication processes. These connections highlight its potential as a therapeutic target in disease management.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com