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AB121488

Anti-TMEM45B antibody

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(1 Publication)

Rabbit Polyclonal TMEM45B antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Transmembrane protein 45B aa 50-100.

View Alternative Names

Transmembrane protein 45B, TMEM45B

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM45B antibody (AB121488)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM45B antibody (AB121488)

ab121488, at 1/90 dilution, staining TMEM45B in paraffin-embedded Human duodenum tissue by Immunohistochemistry, showing positivity in glandular cells.

Immunocytochemistry/ Immunofluorescence - Anti-TMEM45B antibody (AB121488)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TMEM45B antibody (AB121488)

Immunofluorescent staining of Human cell line U-251MG shows positivity in nucleus but not nucleoli and cytoplasm. Recommended concentration of ab121488 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Transmembrane protein 45B aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

Q96B21

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Recommend PFA Fixation and Triton X-100 treatment</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM45B also known as Transmembrane Protein 45B is a protein encoded by the TMEM45B gene. It has a molecular mass of approximately 27 kDa. This protein is a multi-pass membrane protein implicated in cellular processes due to its location within the membrane. TMEM45B is expressed in various tissues including high expression in the liver kidney and certain brain regions indicating its diverse roles in different organ systems.
Biological function summary

TMEM45B plays a role in cellular homeostasis and signaling. This protein might interact with other transmembrane proteins to contribute to membrane dynamics and cellular communication. Although TMEM45B is not part of a well-defined protein complex its functional relevance is evident from expression studies and bioinformatics analysis. The precise biological mechanisms are still under investigation but roles in modulating cell-surface receptor activity have been suggested.

Pathways

TMEM45B is involved in pathways related to cell adhesion and signaling. It is implicated in the cell adhesion pathway connecting with proteins like integrins which are vital for cell attachment and migration. Moreover TMEM45B also participates in signaling pathways that regulate cellular growth where it interacts with growth factor receptors to influence cell proliferation. These connections highlight TMEM45B's role in maintaining cellular architecture and responding to environmental stimulations.

TMEM45B has a connection to cancer and metabolic disorders. Alterations in its expression or function can lead to aberrant cell growth linking it to tumorigenesis. Studies indicate potential interactions with proteins such as EGFR which is significantly involved in many cancers. Additionally TMEM45B is linked to insulin resistance affecting the metabolic pathway and contributing to disorders like type 2 diabetes. This association with metabolic and proliferative pathologies makes TMEM45B a target of interest for therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in innate immunity (PubMed : 35938871). Mechanistically, promotes alphaviruses RNA degradation by interacting with the viral polymerase nsP4 and the mRNA-capping enzyme nsP1 and thereby interfering with the interaction between viral RNA and nsP1 (PubMed : 35938871). Essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity (By similarity).
See full target information Transmembrane protein 45B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

General physiology and biophysics 40:103-114 PubMed33880997

2021

circ_LRIG3 contributes to the progression of hepatocellular carcinoma by elevating RNF38 via sponging miR-449a.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaonan Hu,Kaikai Zhou,Sujuan Cao,Huan Zhu,Kaihong Xie
View all publications
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Product promise

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