Rabbit Polyclonal TMEM59 antibody. Suitable for WB, IF, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMEM59.
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Publications
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- International journal of genomics 2023:99426632023An Analysis of the Gene Expression Associated with Lymph Node Metastasis in Colorectal Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHongjie Yang,Jiafei Liu,Peishi Jiang,Peng Li,Yuanda Zhou,Zhichun Zhang,Qingsheng Zeng,Min Wang,Luciena Xiao Xiao,Xipeng Zhang,Yi Sun,Siwei ZhuPubMed 37719786
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TMEM59. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BXS4
Reactivity data
Select an application| WB | IF | IHC-P | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1.00000-2.00000 µg/mL | Notes - |
IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Associated Products
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Target data
Function
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:23376921, PubMed:27273576). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).
Alternative names
C1orf8, HSPC001, UNQ169/PRO195, TMEM59, Transmembrane protein 59, Liver membrane-bound protein
Recommended products
Rabbit Polyclonal TMEM59 antibody. Suitable for WB, IF, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMEM59.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TMEM59. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BXS4
- Purification technique
- Affinity purification Immunogen
- Specificity
Multiple isoforms of TMEM59 are known to exist. This antibody is predicted to not cross-react with other TMEM family members.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TMEM59 also known as Transmembrane Protein 59 plays a role in protein glycosylation and modulation of the cell surface expression of certain proteins. It has a molecular mass of approximately 39 kDa. TMEM59 is expressed in a variety of tissues including the brain lung and kidney where it localizes to the endoplasmic reticulum and Golgi apparatus. The protein's structure suggests membrane spanning properties that contribute to its function in cell regulation.
- Biological function summary
TMEM59 contributes to proper neuronal function by modulating the cell surface expression of proteins involved in neuron-neuron communications. This regulation has implications for membrane protein function and synaptic stability. TMEM59 participates in certain bionetworks interacting with protein complexes that influence cell signaling pathways. Such interactions play significant roles in controlling protein trafficking and localization within cells impacting the cellular response to environmental signals.
- Pathways
TMEM59 influences processes like the Wnt signaling pathway affecting cell fate decisions and embryonic development. It interacts with proteins such as β-catenin and affects their stability and function. TMEM59 also participates in the autophagy-dependent pathways modulating cellular mechanisms involved in the degradation of damaged proteins and organelles therefore maintaining cellular homeostasis.
- Associated diseases and disorders
TMEM59 has links to neurodegenerative diseases including Alzheimer's disease and schizophrenia. TMEM59's regulation of proteins like APP (Amyloid precursor protein) is significant. Disruptions in its function may contribute to aberrant protein aggregation commonly seen in Alzheimer's disease pathology. Additionally disruptions in TMEM59 expression or function could affect cognitive processes and synaptic connections related to schizophrenia as it influences the trafficking of receptor proteins important for synaptic signaling.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-TMEM59 antibody (ab105417)
All lanes: Western blot - Anti-TMEM59 antibody (ab105417) at 1 µg/mL
Lane 1: Human kidney tissue lysate at 15 µg
Lane 2: Human kidney tissue lysate at 15 µg with blocking peptide
Predicted band size: 36 kDa
Immunofluorescence - Anti-TMEM59 antibody (ab105417)
Immunofluorescence of TMEM59 in Human kidney tissue with ab105417 at 20 ug/mL.
Immunohistochemistry paraffin embedded sections - Anti-TMEM59 antibody (ab105417)
Immunohistochemistry of TMEM59 in human kidney tissue with ab105417 at 2.5 µg/ml.
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