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AB185227

Anti-TMEM59L antibody [EPR14975]

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(1 Publication)

Rabbit Recombinant Monoclonal TMEM59L antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

BSMAP, C19orf4, TMEM59L, Transmembrane protein 59-like, Brain-specific membrane-anchored protein

2 Images
Western blot - Anti-TMEM59L antibody [EPR14975] (AB185227)
  • WB

Supplier Data

Western blot - Anti-TMEM59L antibody [EPR14975] (AB185227)

All lanes:

Western blot - Anti-TMEM59L antibody [EPR14975] (ab185227) at 1/2000 dilution

All lanes:

293 cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 38 kDa

false

Western blot - Anti-TMEM59L antibody [EPR14975] (AB185227)
  • WB

Supplier Data

Western blot - Anti-TMEM59L antibody [EPR14975] (AB185227)

All lanes:

Western blot - Anti-TMEM59L antibody [EPR14975] (ab185227) at 1/10000 dilution

All lanes:

Human cerebellum cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 38 kDa

false

  • Carrier free

    Anti-TMEM59L antibody [EPR14975] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR14975

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM59L also known as Transmembrane Protein 59-Like is a protein with an approximate mass of 43 kDa. This protein is usually expressed in the brain with higher levels detected in regions like the cerebral cortex and hippocampus. TMEM59L is a type I transmembrane protein which means it spans the cellular membrane once and its N-terminal is inside the extracellular space. Its structure suggests a role in cellular signaling and membrane dynamics although its distinct functional domains are not entirely mapped yet.
Biological function summary

TMEM59L acts in neural differentiation and synaptic function. The protein influences neuronal development and may also play a role in synapse formation and maintenance. It is not known to be part of a larger multiprotein complex strictly but it interacts with several cellular components involved in neuronal plasticity. The presence of TMEM59L in neuronal tissue suggests that it contributes significantly to processes integral to cognitive functions.

Pathways

TMEM59L participates in cerebral processes involving cellular communication and neural integrity. It interacts within the Wnt signaling pathway which is important for neurite outgrowth and synaptic plasticity. This pathway involves other proteins such as Disheveled (DVL) and beta-catenin which further highlight the role of TMEM59L in neural connectivity and growth. In addition TMEM59L's interactions may influence pathways related to receptor trafficking connecting it to cytoskeleton-associated proteins.

TMEM59L links to neurodegenerative conditions including Alzheimer's disease and cognitive decline. In Alzheimer's disease irregularities in the expression or function of TMEM59L might disturb normal synaptic activity or neuronal health. This protein relates to beta-amyloid precursor protein (APP) which plays a role in disease pathology. Changes in TMEM59L could also affect neural plasticity leading to cognitive impairments suggesting that it might serve as a biomarker or therapeutic target in addressing such disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.
See full target information TMEM59L
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell research : PubMed32686767

2020

Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Pei Chen,Jian-Hua Yin,Wen-Fei Li,Han-Jie Li,Dong-Ping Chen,Cui-Juan Zhang,Jia-Wei Lv,Ya-Qin Wang,Xiao-Min Li,Jun-Yan Li,Pan-Pan Zhang,Ying-Qin Li,Qing-Mei He,Xiao-Jing Yang,Yuan Lei,Ling-Long Tang,Guan-Qun Zhou,Yan-Ping Mao,Chen Wei,Ke-Xu Xiong,Hong-Bo Zhang,Shi-Da Zhu,Yong Hou,Ying Sun,Michael Dean,Ido Amit,Kui Wu,Dong-Ming Kuang,Gui-Bo Li,Na Liu,Jun Ma
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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