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AB236862

Anti-TMEM68 antibody

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(1 Publication)

Rabbit Polyclonal TMEM68 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM68 aa 50-150.

View Alternative Names

DGAT1/2-independent enzyme synthesizing storage lipids, DIESL, Monoacylglycerol/Diacylglycerol O-acyltransferase, Transmembrane protein 68, MGAT/DGAT, TMEM68

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-TMEM68 antibody (AB236862)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TMEM68 antibody (AB236862)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling TMEM68 using ab236862 at 1/100 dilution in ICC/IF. Secondary antibody was Alexa Fluor® 488-conjugated goat anti-rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human TMEM68 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q96MH6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM68 also known as transmembrane protein 68 acts as an enzyme involved in various cellular processes. It has a molecular mass of approximately 26 kDa. This protein is expressed in several tissues with high levels found in adipose tissue skeletal muscle and the liver. Its localization includes the endoplasmic reticulum membrane suggesting a role in membrane-associated functions.
Biological function summary

TMEM68 participates in lipid metabolism facilitating processes related to lipid synthesis and breakdown. Although not directly part of a larger protein complex it interacts closely with molecular structures involved in metabolic pathways. TMEM68's enzymatic activities influence critical cellular components and maintain lipid homeostasis ensuring cells efficiently process and utilize lipid resources.

Pathways

Several critical metabolic routes engage TMEM68 activities. Notably it plays a role in the fatty acid metabolism pathway. TMEM68 interacts with critical enzymes like acetyl-CoA carboxylase and fatty acid synthase aiding in the synthesis and degradation of lipids. These interactions reflect TMEM68's integration into metabolic assemblies that manage energy storage and release within cells.

Altered TMEM68 expression links to metabolic conditions such as obesity and type 2 diabetes. Abnormal activity of this protein affects lipid regulation and leads to dysregulated metabolic states. TMEM68 links to proteins involved in insulin signaling pathways like insulin receptor substrate 1 (IRS1) which further impacts the development and progression of these diseases. Understanding TMEM68's role in such disorders highlights potential therapeutic targets for metabolic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalytic subunit of the alternative triglyceride biosynthesis pathway, which mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed : 37648867). Synthesizes triacylglycerol at the expense of membrane phospholipids, such as phosphatidylcholine (PC) and its ether-linked form (ePC), thereby altering the composition of membranes (PubMed : 37648867). The alternative triglyceride biosynthesis pathway is probably required to provide the energy required for rapid growth when fuel sources are limiting (PubMed : 37648867). It maintains mitochondrial function during periods of extracellular lipid starvation (PubMed : 37648867). Can also use acyl-CoA as donor : acts as a acyl-CoA : monoacylglycerol acyltransferase (MGAT), but also shows acyl-CoA : diacylglycerol acyltransferase (DGAT) activity (By similarity).
See full target information TMEM68
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncogene 43:931-943 PubMed38341472

2024

TMEM65 promotes gastric tumorigenesis by targeting YWHAZ to activate PI3K-Akt-mTOR pathway and is a therapeutic target.

Applications

Unspecified application

Species

Unspecified reactive species

Lingxue Shi,Xiaohong Wang,Shang Guo,Hongyan Gou,Haiyun Shang,Xiaojia Jiang,Chunxian Wei,Jia Wang,Chao Li,Lihong Wang,Zengren Zhao,Weifang Yu,Jun Yu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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