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AB235788

Anti-TMEM71 antibody

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(2 Publications)

Rabbit Polyclonal TMEM71 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM71 aa 1-250.

View Alternative Names

Transmembrane protein 71, TMEM71

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM71 antibody (AB235788)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM71 antibody (AB235788)

Paraffin-embedded human gastric cancer tissue stained for TMEM71 using ab235788 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM71 antibody (AB235788)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM71 antibody (AB235788)

Paraffin-embedded human colon cancer tissue stained for TMEM71 using ab235788 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-TMEM71 antibody (AB235788)
  • WB

Supplier Data

Western blot - Anti-TMEM71 antibody (AB235788)

All lanes:

Western blot - Anti-TMEM71 antibody (ab235788) at 1/1000 dilution

Lane 1:

U937 (human histiocytic lymphoma cell line) whole cell lysate

Lane 2:

U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 33 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TMEM71 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q6P5X7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM71 also known as transmembrane protein 71 is an integral membrane protein with a mass of approximately 24 kDa. This protein is embedded within cellular membranes and exhibits expression across various tissues though more noticeable in the central nervous system. It contains several transmembrane domains which allow it to play a role in cellular transport and communication processes within the membrane. TMEM71's expression pattern suggests a role in maintaining cellular homeostasis.
Biological function summary

TMEM71 participates in intracellular signaling and transport processes. It does not function alone but often associates with other membrane proteins facilitating the transfer and modulation of signaling molecules across the cell membrane. Its ability to interact with different molecules points to its involvement in regulating cellular responses and maintaining equilibrium within cells.

Pathways

TMEM71's involvement spans several biological functions that include cellular signaling and transport. An important pathway it partakes in is the MAPK signaling pathway where it can interact with proteins like ERK1/2. This interaction aids in the regulation of cellular responses to external stimuli and phosphorylation events. Furthermore TMEM71 may influence calcium signaling pathways interacting with calcium-binding proteins to affect cellular contraction and neurotransmission.

TMEM71 has shown a connection to neurological disorders particularly those involving disrupted cellular signaling such as epilepsy. Abnormal expression or mutations in TMEM71 can influence the function of associated proteins such as those in the MAPK pathway which are important in neural cell communication. Additionally there is preliminary evidence linking TMEM71 to certain cancer types where its dysregulated expression might impact pathways essential for tumor progression and survival in association with proteins like MEK and RAF.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TMEM71
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 25:109 PubMed40119335

2025

TMEM71 is crucial for cell proliferation in lower-grade glioma and is linked to unfavorable prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Jiabao Xie,Wanli Yu,Shikai Gui,Lunshan Peng,Juexian Xiao,Haitao Luo,Zujue Cheng

OncoTargets and therapy 14:3721-3728 PubMed34140780

2021

G9a Regulates Cell Sensitivity to Radiotherapy via Histone H3 Lysine 9 Trimethylation and CCDC8 in Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yunfen Li,Zhengting Chen,Ke Cao,Lan Zhang,Yuhui Ma,Shuhui Yu,Hanyu Jin,Xiaoling Liu,Wenhui Li
View all publications
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