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AB185453

Anti-TMEM79 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal TMEM79 antibody. N-terminal. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM79 aa 1-100.

View Alternative Names

MATT, TMEM79, Transmembrane protein 79, Mattrin

6 Images
Immunocytochemistry/ Immunofluorescence - Anti-TMEM79 antibody - N-terminal (AB185453)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TMEM79 antibody - N-terminal (AB185453)

MCF7 cells stained for TMEM79 (green) using ab185453 at 2 μg/ml dilution in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM79 antibody - N-terminal (AB185453)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM79 antibody - N-terminal (AB185453)

Paraffin embedded human testis prostate stained for TMEM79 using ab185453 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM79 antibody - N-terminal (AB185453)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM79 antibody - N-terminal (AB185453)

Paraffin embedded human skin tissue stained for TMEM79 using ab185453 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM79 antibody - N-terminal (AB185453)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM79 antibody - N-terminal (AB185453)

Paraffin embedded human skin prostate stained for TMEM79 using ab185453 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM79 antibody - N-terminal (AB185453)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM79 antibody - N-terminal (AB185453)

Paraffin embedded human liver tissue stained for TMEM79 using ab185453 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

Western blot - Anti-TMEM79 antibody - N-terminal (AB185453)
  • WB

Supplier Data

Western blot - Anti-TMEM79 antibody - N-terminal (AB185453)

All lanes:

Western blot - Anti-TMEM79 antibody - N-terminal (ab185453) at 1/100 dilution

All lanes:

RT-4 cell line lysate

Predicted band size: 44 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TMEM79 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9BSE2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM79 also known as Mato is a transmembrane protein with an approximate mass of 42 kDa. This protein localizes mostly in the skin where it plays a role in maintaining skin barrier function. Expression of TMEM79 happens predominantly in keratinocytes which are the principal cells forming the epidermis. The protein comprises several transmembrane domains suggesting its role in cell membrane-related activities. Its mechanical action involves interactions at the cellular surface level important for skin cell communication and function.
Biological function summary

TMEM79 influences skin integrity and homeostasis. This protein does not typically form part of larger protein complexes but acts independently to safeguard skin barrier function. TMEM79 contributes to the structure and function of the stratum corneum the outermost layer of the skin which protects against environmental aggressors. Its activity helps regulate processes important for cellular adhesion and differentiation which are essential for maintaining healthy skin.

Pathways

TMEM79 participates in the processes tied to barrier homeostasis and skin differentiation. Its function is notably significant in the epidermal differentiation complex. TMEM79 interacts with key proteins such as filaggrin and loricrin both critical for maintaining the protective layer of the skin. These interactions assist in optimizing the skin's response to physical and chemical stresses ensuring an intact and functional epidermal barrier.

TMEM79 has been directly linked to atopic dermatitis and ichthyosis vulgaris. Variations in TMEM79 may lead to disrupted skin barrier function increasing susceptibility to these conditions. Research indicates interactions between TMEM79 and the protein filaggrin are essential. Filaggrin mutations have also been associated with atopic dermatitis highlighting the importance of TMEM79 in these dermatological disorders. Through its role and interactions TMEM79 proves to be a significant factor in skin health and disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity).
See full target information TMEM79
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 22:168 PubMed38454413

2024

TMEM160 promotes tumor immune evasion and radiotherapy resistance via PD-L1 binding in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofeng Dai,Zhipeng Wu,Ruiwen Ruan,Jingyi Chen,Chunye Huang,Wan Lei,Yangyang Yao,Li Li,Xiaomei Tang,Jianping Xiong,Miao Feng,Jun Deng
View all publications
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Product promise

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