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AB173455

Anti-TMEM86B antibody

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(1 Publication)

Rabbit Polyclonal TMEM86B antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Lysoplasmalogenase.

View Alternative Names

Lysoplasmalogenase TMEM86B, Transmembrane protein 86B, TMEM86B

1 Images
Western blot - Anti-TMEM86B antibody (AB173455)
  • WB

Supplier Data

Western blot - Anti-TMEM86B antibody (AB173455)

All lanes:

Western blot - Anti-TMEM86B antibody (ab173455) at 1 µg/mL

Lane 1:

TMEM86B transfected 293T cell line lysate at 15 µL

Lane 2:

Non-transfected 293T cell line lysate at 15 µL

Secondary

All lanes:

Goat anti-Rabbit IgG at 1/7500 dilution

Predicted band size: 24 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Lysoplasmalogenase.

Q8N661

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM86B also known as Transmembrane Protein 86B is a protein that functions as a lysosomal membrane protein and has a mass of approximately 29 kDa. It is part of a broader family of proteins involved in lysosomal activity. TMEM86B is expressed in various tissues with higher levels found in the brain liver and immune cells. Its structure suggests its involvement in maintaining lysosomal function although detailed mechanisms remain under investigation.
Biological function summary

The protein plays a critical role in lysosome-related processes by supporting lysosomal acidification and protein trafficking. TMEM86B may associate with other lysosomal proteins to form a functional complex possibly influencing lysosomal dynamics. Its expression can impact cellular homeostasis contributing to the breakdown and recycling of biomolecules. Studies indicate a link between TMEM86B activity and autophagy a process important for cell health and turnover.

Pathways

TMEM86B is associated with the lysosomal signaling pathways and connected to broader cellular processes like autophagy and the endosomal-lysosomal transport pathway. It interacts with proteins like LAMP2 involved in transporting substances within the cell and may influence the mTOR signaling pathway via lysosomal involvement. This influence can affect cellular growth and response to nutrient availability.

Mutations or irregular expression of TMEM86B may relate to neurodegenerative diseases such as Parkinson's Disease and metabolic disorders impacting lysosomal function. There is evidence linking TMEM86B to Gaucher's disease a disorder resulting from impaired lysosomal enzyme activity. The protein's connection to LAMP2 and similar proteins suggests its potential role in these conditions highlighting the importance of lysosomal integrity in disease prevention and management.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen.
See full target information Lysoplasmalogenase
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2402509 PubMed38590132

2024

Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification.

Applications

Unspecified application

Species

Unspecified reactive species

Bairen Pang,Qi Wang,Haotian Chen,Zhihan Liu,Meng Han,Jie Gong,Liang Yue,Xuan Ding,Suying Wang,Zejun Yan,Yingzhi Chen,David Malouf,Joseph Bucci,Tiannan Guo,Cheng Zhou,Junhui Jiang,Yong Li
View all publications
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