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AB236864

Anti-TMEM91 antibody

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(1 Publication)

Rabbit Polyclonal TMEM91 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM91 aa 1-100.

View Alternative Names

Transmembrane protein 91, Dispanin subfamily C member 3, DSPC3, TMEM91

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM91 antibody (AB236864)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM91 antibody (AB236864)

Paraffin-embedded human liver cancer tissue stained for TMEM91 using ab236864 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-TMEM91 antibody (AB236864)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TMEM91 antibody (AB236864)

MCF7 (human breast adenocarcinoma cell line) cells stained for TMEM91 (green) using ab236864 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM91 antibody (AB236864)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM91 antibody (AB236864)

Paraffin-embedded human small intestine tissue stained for TMEM91 using ab236864 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-TMEM91 antibody (AB236864)
  • WB

Supplier Data

Western blot - Anti-TMEM91 antibody (AB236864)

All lanes:

Western blot - Anti-TMEM91 antibody (ab236864) at 1/1000 dilution

All lanes:

A549 (human lung carcinoma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 18 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TMEM91 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q6ZNR0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM91 also known as Transmembrane Protein 91 acts as an integral membrane protein with a proposed role in cellular transport processes. Its mass is approximately 31 kDa. It shows high expression in several tissues including the lung liver and kidney indicating its potential significance in these areas. TMEM91 contains several transmembrane domains that suggest involvement in the transport or signaling functions.
Biological function summary

This protein contributes to intracellular transport and cellular signaling processes. TMEM91 does not currently have a confirmed association with any multi-protein complexes. However it interacts with cellular membranes influencing various transport activities through the lipid bilayer. The structure supports diverse cellular roles adapting to specific tissue demands where high expression occurs.

Pathways

TMEM91 participates actively in intracellular signaling pathways and cellular homeostasis. The mTOR signaling pathway utilizes TMEM91 to regulate cellular metabolism and growth. In addition TMEM91 interacts with MAPK proteins which play a role in proliferation differentiation and stress response signaling pathways. These interactions place TMEM91 at an operational junction where cellular growth and adaptive responses converge.

Research connects TMEM91 to metabolic diseases and certain pulmonary conditions. Abnormalities in TMEM91 expression or function have been associated with metabolic syndrome highlighting its involvement in metabolic regulation. Dysregulation of this protein can also relate to respiratory disorders possibly impacting pathways involving typical partners like mTOR and MAPK leading to pathological states in the lung.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TMEM91
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncogene 43:931-943 PubMed38341472

2024

TMEM65 promotes gastric tumorigenesis by targeting YWHAZ to activate PI3K-Akt-mTOR pathway and is a therapeutic target.

Applications

Unspecified application

Species

Unspecified reactive species

Lingxue Shi,Xiaohong Wang,Shang Guo,Hongyan Gou,Haiyun Shang,Xiaojia Jiang,Chunxian Wei,Jia Wang,Chao Li,Lihong Wang,Zengren Zhao,Weifang Yu,Jun Yu
View all publications
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Product promise

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