Anti-TMF antibody [EPR10671(B)] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Transcriptional mediator factor (TMF) also known as TMF/ARA160 weighs around 160 kDa. It resides in the nucleus and cytoplasm of cells. TMF is a multifunctional protein and plays a part in transcription regulation. It interacts with protein complexes influencing their stability and function. In addition to its nuclear roles TMF associates with the Golgi apparatus suggesting its diverse function in different cellular contexts.

Biological function summary

The role of TMF extends to various cellular processes including transcriptional regulation signal transduction and vesicle transport. It forms part of larger protein complexes which modulate gene expression and cellular signaling networks. TMF serves as a scaffold facilitating the interactions between transcription factors and other regulatory proteins. This makes TMF an active regulator of transcriptional control impacting gene expression patterns.

Pathways

Many known cellular pathways require TMF's involvement. TMF impacts the NF-kappaB signaling pathway and the Wnt signaling pathway. It directly interacts with proteins like RelA in the NF-kappaB pathway where it modulates transcriptional activation. TMF's influence on these pathways highlights its significant role in regulating cellular responses and maintaining cellular homeostasis.

Associated diseases and disorders

Research shows that TMF has associations with cancer and neurodegenerative diseases. Its abnormal expression or mutation links to tumorigenesis particularly in cancers such as prostate and breast cancer. Its interaction with proteins such as beta-catenin in the Wnt pathway associates TMF with oncogenic processes. Moreover TMF's role in the Golgi apparatus links it to neurodegenerative disorders where disruptions in vesicle transport are common features.