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AB121333

Anti-TMIGD2/IGPR1 antibody

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(2 Publications)

Rabbit Polyclonal TMIGD2/IGPR1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMIGD2 aa 1-150.

View Alternative Names

CD28H, IGPR1, UNQ3059/PRO9879, TMIGD2, Transmembrane and immunoglobulin domain-containing protein 2, CD28 homolog, Immunoglobulin and proline-rich receptor 1, IGPR-1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMIGD2/IGPR1 antibody (AB121333)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMIGD2/IGPR1 antibody (AB121333)

ab121333, at 1/50, staining TMIGD2/IGPR1 in paraffin embedded Human duodenum tissue by Immunohistochemistry.

Western blot - Anti-TMIGD2/IGPR1 antibody (AB121333)
  • WB

Unknown

Western blot - Anti-TMIGD2/IGPR1 antibody (AB121333)

All lanes:

Western blot - Anti-TMIGD2/IGPR1 antibody (ab121333) at 1/250 dilution

Lane 1:

Negative control (vector only transfected HEK293T lysate)

Lane 2:

Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells

Predicted band size: 31 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TMIGD2 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q96BF3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMIGD2 also known as IGPR1 (Immuno-Glycosylation Promoting Receptor 1) is a protein that functions as a transmembrane receptor. It has a molecular weight of approximately 50 kDa. TMIGD2 is expressed on the surface of endothelial cells and some lymphocytes notably T cells. The protein has a specific expression pattern which restricts it to certain tissues indicating its specialized role in cellular communication and interaction.
Biological function summary

This protein functions in the regulation of cell-cell adhesions impacting cell signaling and the maintenance of endothelial barriers. TMIGD2/IGPR1 does not function alone but associates homophilically binding to itself on adjacent cells to mediate cellular communication. This interaction plays a pivotal role in stabilizing intercellular connections which are essential for the proper function of vascular systems. Studies suggest its role in modulating immune cell interactions and migration.

Pathways

TMIGD2/IGPR1 interfaces significantly with the cellular adhesion and immune response pathways. It is involved in adhesive interactions that are integral to the function of these pathways. TMIGD2 interacts with proteins involved in the vascular endothelial growth factor (VEGF) pathway influencing angiogenesis and vascular integrity. Additionally it has links to the cell signaling pathways involving integrins which serve as important mediators in cellular attachment and migration.

Research associates TMIGD2/IGPR1 with vascular-related conditions such as atherosclerosis and inflammation-related diseases. Its expression patterns influence endothelial cell response and immune cell trafficking important elements in these conditions. In atherosclerosis the protein's interaction with adhesion molecules like ICAM-1 and VCAM-1 can alter the inflammatory environment influencing disease progression. In inflammatory diseases TMIGD2's modulatory effects on immune cell dynamics can exacerbate or alleviate disease states depending on the context.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
See full target information TMIGD2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 15:1524861 PubMed40061889

2025

Prognostic significance of the inhibitory-to-stimulatory immune checkpoint ratio in patients with breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Chuangang Tang,Xiang Hu,Dawei Hao,Tao Chen,Pei Wang,Changwen Li,Chengling Chen,Yongcheng Li,Xiaowen Hao,Zeng Yuan

Biochemical genetics 59:453-474 PubMed33098307

2020

miR-491-3p is Downregulated in Retinoblastoma and Inhibit Tumor Cells Growth and Metastasis by Targeting SNN.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Hu,Ming Zhao,Li Li,Jie Ding,Yu-Min Gui,Tan-Wei Wei
View all publications
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