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AB127031

Anti-TMPRSS11D antibody

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(1 Review)

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(9 Publications)

Rabbit Polyclonal TMPRSS11D antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMPRSS11D aa 150-350.

View Alternative Names

HAT, TMPRSS11D, Transmembrane protease serine 11D, Airway trypsin-like protease

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-TMPRSS11D antibody (AB127031)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TMPRSS11D antibody (AB127031)

Immunofluorescence analysis of A431 cells fixed in 4% paraformaldehyde at RT for 15 min labelling secreted TMPRSS11D protein using ab127031 at a 1/500 dilution (Green).
Hoechst 33342 was used for nuclear staining (Blue). Scale bar = 10 µm

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMPRSS11D antibody (AB127031)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMPRSS11D antibody (AB127031)

Immunohistochemical analysis of paraffin-embedded MCF7 xenograft tissue stained for TMPRSS11D protein at cell membrane and cytoplasm with ab127031 at a 1/500 dilution.

Antigen retrieval : Citrate buffer, pH 6.0, 15 min.

Western blot - Anti-TMPRSS11D antibody (AB127031)
  • WB

Supplier Data

Western blot - Anti-TMPRSS11D antibody (AB127031)

Samples were separated by 10% SDS-PAGE.

All lanes:

Western blot - Anti-TMPRSS11D antibody (ab127031) at 1/500 dilution

All lanes:

A431 Whole cell extract at 30 µg

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human TMPRSS11D aa 150-350. The exact immunogen used to generate this antibody is proprietary information.

O60235

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Store undiluted.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.
See full target information TMPRSS11D
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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 134: PubMed39286971

2024

SARS-CoV-2 Delta and Omicron variants resist spike cleavage by human airway trypsin-like protease.

Applications

Unspecified application

Species

Unspecified reactive species

Wenyan Ren,Weiqi Hong,Jingyun Yang,Jun Zou,Li Chen,Yanan Zhou,Hong Lei,Aqu Alu,Haiying Que,Yanqiu Gong,Zhenfei Bi,Cai He,Minyang Fu,Dandan Peng,Yun Yang,Wenhai Yu,Cong Tang,Qing Huang,Mengli Yang,Bai Li,Jingmei Li,Junbin Wang,Xuelei Ma,Hongbo Hu,Wei Cheng,Haohao Dong,Jian Lei,Lu Chen,Xikun Zhou,Jiong Li,Wei Wang,Guangwen Lu,Guobo Shen,Li Yang,Jinliang Yang,Zhenling Wang,Guowen Jia,Zhaoming Su,Bin Shao,Hanpei Miao,Johnson Yiu-Nam Lau,Yuquan Wei,Kang Zhang,Lunzhi Dai,Shuaiyao Lu,Xiawei Wei

International wound journal 21:e14447 PubMed38149752

2023

Molecular characterization of chronic cutaneous wounds reveals subregion- and wound type-specific differential gene expression.

Applications

Unspecified application

Species

Unspecified reactive species

Shola Michelle Richards,Caroline Gubser Keller,Robert Kreutzer,Géraldine Greiner,Svenja Ley,Arno Doelemeyer,Valerie Dubost,Thierry Flandre,Susan Kirkland,Walter Carbone,Rishika Pandya,Judith Knehr,Guglielmo Roma,Sven Schuierer,Laure Bouchez,Klaus Seuwen,Alexandra Aebi,David Westhead,Gabriele Hintzen,Giorgia Jurisic,Imtiaz Hossain,Marilisa Neri,Nenad Manevski,Kamal Kumar Balavenkatraman,Pierre Moulin,Annette Begrich,Barbara Bertschi,Roland Huber,Tewis Bouwmeester,Vickie R Driver,Moritz von Schwabedissen,Dirk Schaefer,Barbara Wettstein,Reto Wettstein,Heinz Ruffner

Dermatology (Basel, Switzerland) 238:236-243 PubMed34077928

2021

3D-SeboSkin Model for Human ex vivo Studies of Hidradenitis Suppurativa/Acne Inversa.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxiao Hou,Amir M Hossini,Georgios Nikolakis,Ottfried Balthasar,Andreas Kurtz,Christos C Zouboulis

American journal of physiology. Lung cellular and 319:L670-L674 PubMed32878480

2020

Elevated FiO increases SARS-CoV-2 co-receptor expression in respiratory tract epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Despoina Myti,Miša Gunjak,Francisco Casado,Solmaz Khaghani Raziabad,Claudio Nardiello,István Vadász,Susanne Herold,Gloria Pryhuber,Werner Seeger,Rory E Morty

Journal of the European Academy of Dermatology and Venereology : JEADV 34:846-861 PubMed31838778

2020

Alterations in innate immunity and epithelial cell differentiation are the molecular pillars of hidradenitis suppurativa.

Applications

Unspecified application

Species

Unspecified reactive species

C C Zouboulis,A Nogueira da Costa,E Makrantonaki,X X Hou,D Almansouri,J T Dudley,H Edwards,B Readhead,O Balthasar,G B E Jemec,N G Bonitsis,G Nikolakis,D Trebing,K C Zouboulis,A M Hossini

RSC advances 9:21591-21600 PubMed35521321

2019

Retracted Article: Knockdown of TMPRSS11D inhibits the proliferation, migration and invasion of cervical cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Kun Yan,Chunyan Hu,Chen Liu,Guanghua Chu,Xinru Wang,Shuyun Ma,Long Li

F1000Research 7:1666 PubMed30647911

2018

Functional proteomic profiling reveals KLK13 and TMPRSS11D as active proteases in the lower female reproductive tract.

Applications

Unspecified application

Species

Unspecified reactive species

Carla M J Muytjens,Yijing Yu,Eleftherios P Diamandis

Oncotarget 8:12812-12819 PubMed28086212

2017

High TMPRSS11D protein expression predicts poor overall survival in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiang Cao,Zhiyuan Tang,Fang Huang,Qin Jin,Xiaoyu Zhou,Jiahai Shi

Journal of cellular physiology 231:1476-83 PubMed26297835

2016

Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Michael J Duhaime,Khaliph O Page,Fausto A Varela,Andrew S Murray,Michael E Silverman,Gina L Zoratti,Karin List
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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