AB59862

Anti-TMPRSS13 antibody - Cytoplasmic domain

Name: Anti-TMPRSS13 antibody - Cytoplasmic domain (ab59862) | Abcam
Brand: Abcam Limited
SKU: AB59862
Price: 525 USD
Availability: InStock

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(6 Publications)

Rabbit Polyclonal TMPRSS13 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human TMPRSS13.

View Alternative Names

MSP, TMPRSS11, TMPRSS13, Transmembrane protease serine 13, Membrane-type mosaic serine protease, Mosaic serine protease

1 Images

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Western blot - Anti-TMPRSS13 antibody - Cytoplasmic domain (AB59862)

All lanes:

Western blot - Anti-TMPRSS13 antibody - Cytoplasmic domain (ab59862) at 1/1000 dilution

Lane 1:

Cell media from human prostate adenocarcinoma LNCaP cells (treated with SF) at 20 µL

Lane 2:

Cell media from human prostate adenocarcinoma LNCaP cells (treated with TPA) at 20 µL

Lane 3:

Cell media from human prostate adenocarcinoma LNCaP cells (treated with IL1-alpha) at 20 µL

Predicted band size: 63 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human TMPRSS13. The exact immunogen used to generate this antibody is proprietary information.

Q9BYE2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 2.9% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Serine protease (PubMed : 20977675, PubMed : 28710277, PubMed : 34562451). Cleaves the proform of PRSS8/prostasin to form the active protein (PubMed : 34562451). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (PubMed : 20977675). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity).

See full target information TMPRSS13

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 13:982839 PubMed36131918

2022

IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike.

Applications

Unspecified application

Species

Unspecified reactive species

Jérôme Gatineau,Charlotte Nidercorne,Aurélie Dupont,Marie-Line Puiffe,José L Cohen,Valérie Molinier-Frenkel,Florence Niedergang,Flavia Castellano

mBio 13:e0137622 PubMed35913162

2022

Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease.

Applications

Unspecified application

Species

Unspecified reactive species

Annelies Stevaert,Ria Van Berwaer,Cato Mestdagh,Julie Vandeput,Els Vanstreels,Valerie Raeymaekers,Manon Laporte,Lieve Naesens

Biological chemistry 403:969-982 PubMed35796294

2022

TMPRSS13 zymogen activation, surface localization, and shedding is regulated by proteolytic cleavage within the non-catalytic stem region.

Applications

Unspecified application

Species

Unspecified reactive species

Carly E Martin,Andrew S Murray,Jacob R Mackinder,Kimberley E Sala-Hamrick,Michael G Flynn,Joseph G Lundgren,Fausto A Varela,Karin List

The Journal of biological chemistry 297:101227 PubMed34562451

2021

Posttranslational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization.

Applications

Unspecified application

Species

Unspecified reactive species

Carly E Martin,Andrew S Murray,Kimberley E Sala-Hamrick,Jacob R Mackinder,Evan C Harrison,Joseph G Lundgren,Fausto A Varela,Karin List

Scientific reports 10:13896 PubMed32807808

2020

TMPRSS13 promotes cell survival, invasion, and resistance to drug-induced apoptosis in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Fausto A Varela,Victoria L Foust,Thomas E Hyland,Kimberley E Sala-Hamrick,Jacob R Mackinder,Carly E Martin,Andrew S Murray,Sokol V Todi,Karin List

The Journal of biological chemistry 292:14867-14884 PubMed28710277

2017

Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew S Murray,Fausto A Varela,Thomas E Hyland,Andrew J Schoenbeck,Jordan M White,Lauren M Tanabe,Sokol V Todi,Karin List

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TMPRSS13 antibody - Cytoplasmic domain

Western blot - Anti-TMPRSS13 antibody - Cytoplasmic domain (AB59862)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Target data

Publications (6)

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