AB82176

Anti-TMPRSS4 antibody

Name: Anti-TMPRSS4 antibody (ab82176) | Abcam
Brand: Abcam Limited
SKU: AB82176
Price: 535 USD
Availability: InStock

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(3 Publications)

Goat Polyclonal TMPRSS4 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TMPRSS4 aa 350-400.

View Alternative Names

TMPRSS3, UNQ776/PRO1570, TMPRSS4, Transmembrane protease serine 4, Channel-activating protease 2, Membrane-type serine protease 2, CAPH2, MT-SP2

1 Images

Supplier Data

Western blot - Anti-TMPRSS4 antibody (AB82176)

Detected by chemiluminescence. 1 hour primary incubation.

All lanes:

Western blot - Anti-TMPRSS4 antibody (ab82176) at 0.5 µg/mL

All lanes:

HEK-293 (human epithelial cell line from embryonic kidney) cell lysate (in RIPA buffer) at 35 µg

Predicted band size: 48 kDa

Observed band size: 48 kDa

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Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human TMPRSS4 aa 350-400. The exact immunogen used to generate this antibody is proprietary information.

Q9NRS4

Specificity

ab82176 is expected to recognize both reported isoforms (NP_063947.1 and NP_001077416.1).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1.5 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab82176 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 0.5% BSA, 0.5% Tris buffered saline

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed : 24434139). Seems to be capable of activating ENaC (By similarity).. (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry.

See full target information TMPRSS4

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Animal cells and systems 25:211-218 PubMed34408809

2021

Type II transmembrane serine proteases 4 (TMPRSS4) promotes proliferation, invasion and epithelial-mesenchymal transition in endometrial carcinoma cells (HEC1A and Ishikawa) via activation of MAPK and AKT.

Applications

Unspecified application

Species

Unspecified reactive species

Huan Xiao,Zhian Zhang,Dan Peng,Chunqing Wei,Benling Ma

International journal of oncology 53:148-158 PubMed29750426

2018

The upregulation of TMPRSS4, partly ascribed to the downregulation of miR‑125a‑5p, promotes the growth of human lung adenocarcinoma via the NF‑κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxi Fan,Yicheng Liang,Yang Liu,Yunpeng Bai,Chunlu Yang,Shun Xu

International journal of molecular medicine 39:927-935 PubMed28259959

2017

Overexpression of TMPRSS4 promotes tumor proliferation and aggressiveness in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Mei Li,Wen-Lou Liu,Xu Chen,Ya-Wen Wang,Duan-Bo Shi,Hui Zhang,Ran-Ran Ma,Hai-Ting Liu,Xiang-Yu Guo,Feng Hou,Ming Li,Peng Gao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TMPRSS4 antibody

Western blot - Anti-TMPRSS4 antibody (AB82176)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (3)

Product promise