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Rat Monoclonal TNF alpha antibody. Suitable for ELISA and reacts with Recombinant fragment - Mouse samples. Cited in 9 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Tnf.

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Key facts

Isotype

IgG1

Host species

Rat

Storage buffer

pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Recombinant Full Length Protein corresponding to Mouse Tnf. Database link P06804
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
ELISA
Recombinant fragment - Mouse
Tested

Tested
Tested

Species

Recombinant fragment - Mouse

Dilution info

1/5

Notes

-

Target data

Function

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (PubMed:25586176). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity).The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

Alternative names

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Rat Monoclonal TNF alpha antibody. Suitable for ELISA and reacts with Recombinant fragment - Mouse samples. Cited in 9 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Tnf.

Alternative names

Key facts

Isotype

IgG1

Form

Liquid

Clonality

Monoclonal

Immunogen

Recombinant Full Length Protein corresponding to Mouse Tnf. Database link P06804

Clone number

MP6-XT3

Purification technique

Affinity purification Protein G

Specificity

ab11564 recognises murine TNF alpha. Reactivity with murine TNF Beta has not yet been determined.

Concentration
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Purification notes

Purified IgG prepared by affinity chromatography from tissue culture supernatant.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

Notes

This product should be stored undiluted.
Should this product contain a precipitate we recommend microcentrifugation before use.

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1 product image

  • ELISA - Anti-TNF alpha antibody [MP6-XT3] (ab11564), expandable thumbnail

    ELISA - Anti-TNF alpha antibody [MP6-XT3] (ab11564)

    Recombinant Mouse TNF alpha detected in a sandwich assay with Rat anti Mouse TNF alpha (ab11564) as the coating antibody; Rabbit anti Mouse TNF alpha:Biotin as the detetction antibody and Streptavidin:HRP as the final layer.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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