Rabbit Polyclonal TNR antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Tenascin-R aa 750-1050.
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Publications
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- Annals of neurology 94:502-5072023Tenascin-R Autoimmunity: Isolated Tremor Reversed with Immunotherapy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBinxia Yang,Andrew Brown,Andrew McKeon,J Eric Ahlskog,Philip Tipton,Yong Guo,Claudia Lucchinetti,Sean J Pittock,Anastasia ZekeridouPubMed 37370243
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human Tenascin-R aa 750-1050. The exact immunogen used to generate this antibody is proprietary information. Database link Q92752
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Expected | Expected |
| Mouse | Tested | Expected |
| Rat | Expected | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).
Alternative names
Tenascin-R, TN-R, Janusin, Restrictin, TNR
Recommended products
Rabbit Polyclonal TNR antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Tenascin-R aa 750-1050.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human Tenascin-R aa 750-1050. The exact immunogen used to generate this antibody is proprietary information. Database link Q92752
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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2 product images
Western blot - Anti-TNR antibody (ab155034)
5% SDS-PAGE
All lanes: Western blot - Anti-TNR antibody (ab155034) at 1/500 dilution
All lanes: Mouse brain tissue lysate at 50 µg
Predicted band size: 15 kDa, 150 kDa, 37 kDa, 41 kDa, 61 kDa
Observed band size: 61 kDa, ~100 kDa, ~120 kDa
Immunocytochemistry/ Immunofluorescence - Anti-TNR antibody (ab155034)
Immunofluorescence analysis 4%paraformaldehyde-fixed (RT for 15 min) DIV9 rat E18 primary hippocampal neuron cells labeling TNR (green) uisng ab155034 at 1/500 dilution. Red: beta Tubulin 3/Tuj1, stained by beta Tubulin 3/Tuj1 antibody at 1/500 dilution. Blue: Fluoroshield with DAPI.
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