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AB221808

Anti-TOR1AIP2 antibody

5

(1 Review)

|

(1 Publication)

Rabbit Polyclonal TOR1AIP2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TOR1AIP2 aa 1-100.
1 Images
Immunocytochemistry/ Immunofluorescence - Anti-TOR1AIP2 antibody (AB221808)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TOR1AIP2 antibody (AB221808)

PFA-fixed, Triton X-100 permeabilized SiHa cells stained for TOR1AIP2 (green) using ab221808 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TOR1AIP2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q8NFQ8

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Primary Antibodies

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Anti-mTOR antibody [Y391]

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Immunohistochemistry (Frozen sections) - Anti-mTOR antibody [Y391] (AB32028)

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Primary Antibodies

AB92477

Anti-TORC1 antibody [EPR3382]

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Primary Antibodies

AB109081

Anti-TORC2 antibody [EPR3384(2)]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TORC2 antibody [EPR3384(2)] (AB109081)

  • 5
  • 4
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TOR1AIP2 also known as LAP2 or Lamina-associated polypeptide 2 is a protein associated with the nuclear envelope. The mass of TOR1AIP2 is approximately 50 kDa. It binds to lamins and chromatin playing a role in nuclear envelope organization. Expressed in various tissues this protein is present in significant amounts in cells undergoing division. TOR1AIP2 localizes mainly in the inner nuclear membrane where it interacts with other components to maintain nuclear structure.
Biological function summary

TOR1AIP2 contributes to nuclear architecture and chromatin organization by forming part of the inner nuclear membrane complex. It helps to tether chromatin to the nuclear envelope ensuring proper chromatin organization. This function is important for DNA replication and chromosome segregation during mitosis. TOR1AIP2 as part of this complex supports the structural integrity of the nucleus and facilitates processes like gene expression regulation.

Pathways

TOR1AIP2 plays roles in pathways related to nuclear envelope composition and stability. It participates in the nuclear envelope assembly pathway alongside proteins such as Emerin and Lamin B. These interactions contribute to the dynamic restructuring of the nuclear envelope during cell division. It also interacts with the nuclear lamina which is vital for maintaining nuclear shape and mechanical stability.

TOR1AIP2 shows associations with muscular dystrophies and cardiomyopathies. Mutations or misregulation of TOR1AIP2 can impact nuclear envelope integrity leading to disorders such as Emery-Dreifuss muscular dystrophy. This happens through its interaction with proteins like Lamin A/C which are also important in maintaining normal nuclear function and structure. Understanding these associations helps in developing therapeutic approaches for nuclear envelope-related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity.
See full target information TOR1AIP2

Alternative Names

IFRG15, LULL1, TOR1AIP2, Torsin-1A-interacting protein 2, Lumenal domain-like LAP1
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Proceedings of the National Academy of Sciences of the United States of America 121:e2404243121 PubMed39331410

2024

Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist.

Applications

Unspecified application

Species

Unspecified reactive species

Federica Liccardo,Johannes Morstein,Ting-Yu Lin,Julius Pampel,Di Lang,Kevan M Shokat,Roshanak Irannejad
View all publications
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Product promise

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