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Mouse Polyclonal TOSO antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FCMR.

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Images

Western blot - Anti-TOSO antibody (AB168968), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TOSO antibody (AB168968), expandable thumbnail

Key facts

Isotype

IgG

Host species

Mouse

Storage buffer

pH: 7.4
Constituents: 100% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Full Length Protein corresponding to Human FCMR. Database link O60667

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested

Tested
Tested

Species

Human

Dilution info

1 µg/mL

Notes

-

Tested
Tested

Species

Human

Dilution info

3 µg/mL

Notes

-

Target data

Function

High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM (PubMed:19858324, PubMed:22675200, PubMed:36949194, PubMed:37095205). Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (PubMed:21908732, PubMed:28230186). Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways (PubMed:19858324, PubMed:22675200, PubMed:25601920, PubMed:30840890).

Alternative names

Recommended products

Mouse Polyclonal TOSO antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FCMR.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Full Length Protein corresponding to Human FCMR. Database link O60667
Purification technique

Affinity purification Protein A

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TOSO also known as FAIM3 or IGFRI acts as a receptor critically involved in the regulation of apoptosis and immune responses. This protein has an approximate molecular mass of 32 kDa. It is heavily expressed on the surface of various immune cells including T and B lymphocytes which are key components in the immune system. TOSO participates in the inhibition of apoptosis by blocking the apoptotic signaling pathway thereby ensuring the survival of immune cells under both normal and stressful conditions.

Biological function summary

TOSO functions by modulating the immune response and ensuring cell survival. It operates as part of a receptor complex that includes Fas Ligand (FasL) and influences the cellular response to apoptotic signals. TOSO's role in this complex helps control cell death which is essential for immune regulation and homeostasis. This control is necessary to prevent excessive immune responses that can damage healthy tissues while ensuring the elimination of infected or cancerous cells.

Pathways

TOSO participates in the apoptotic and immune signaling pathways. Within the apoptotic pathway TOSO interacts with the Fas/FasL system to modulate the susceptibility of cells to programmed cell death. In the immune signaling pathway it is connected with proteins like FLIP and Caspase-8 which are vital in regulating apoptosis and immune cell proliferation. These interactions ensure that cells can withstand apoptotic signals under physiological conditions.

Associated diseases and disorders

Dysregulation of TOSO expression or function has been linked to autoimmune diseases and certain cancers. In autoimmune diseases such as rheumatoid arthritis altered TOSO levels can contribute to pathological immune cell survival exacerbating tissue damage. In cancers like lymphomas TOSO may help tumor cells escape apoptosis aiding in unchecked cell survival and tumor progression. The relationship between TOSO and disease highlights its potential as a therapeutic target alongside proteins like Bcl-2 which are also involved in cell survival and apoptosis regulation.

Product promise

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2 product images

  • Western blot - Anti-TOSO antibody (ab168968), expandable thumbnail

    Western blot - Anti-TOSO antibody (ab168968)

    All lanes: Western blot - Anti-TOSO antibody (ab168968) at 1 µg/mL

    Lane 1: TOSO transfected 293T cell lysate at 15 µL

    Lane 2: Non-transfected 293T cell lysate at 15 µL

    Secondary

    All lanes: Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size: 43 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TOSO antibody (ab168968), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TOSO antibody (ab168968)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling TOSO with ab168968 at 3 μg/ml.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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