Mouse Polyclonal TOSO antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FCMR.
IgG
Mouse
pH: 7.4
Constituents: 100% PBS
Liquid
Polyclonal
WB | IHC-P | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 3 µg/mL | Notes - |
High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM (PubMed:19858324, PubMed:22675200, PubMed:36949194, PubMed:37095205). Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (PubMed:21908732, PubMed:28230186). Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways (PubMed:19858324, PubMed:22675200, PubMed:25601920, PubMed:30840890).
FAIM3, TOSO, FCMR, Immunoglobulin mu Fc receptor, IgM FcR, Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso, FAIM3
Mouse Polyclonal TOSO antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FCMR.
IgG
Mouse
pH: 7.4
Constituents: 100% PBS
Liquid
Polyclonal
Affinity purification Protein A
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
TOSO also known as FAIM3 or IGFRI acts as a receptor critically involved in the regulation of apoptosis and immune responses. This protein has an approximate molecular mass of 32 kDa. It is heavily expressed on the surface of various immune cells including T and B lymphocytes which are key components in the immune system. TOSO participates in the inhibition of apoptosis by blocking the apoptotic signaling pathway thereby ensuring the survival of immune cells under both normal and stressful conditions.
TOSO functions by modulating the immune response and ensuring cell survival. It operates as part of a receptor complex that includes Fas Ligand (FasL) and influences the cellular response to apoptotic signals. TOSO's role in this complex helps control cell death which is essential for immune regulation and homeostasis. This control is necessary to prevent excessive immune responses that can damage healthy tissues while ensuring the elimination of infected or cancerous cells.
TOSO participates in the apoptotic and immune signaling pathways. Within the apoptotic pathway TOSO interacts with the Fas/FasL system to modulate the susceptibility of cells to programmed cell death. In the immune signaling pathway it is connected with proteins like FLIP and Caspase-8 which are vital in regulating apoptosis and immune cell proliferation. These interactions ensure that cells can withstand apoptotic signals under physiological conditions.
Dysregulation of TOSO expression or function has been linked to autoimmune diseases and certain cancers. In autoimmune diseases such as rheumatoid arthritis altered TOSO levels can contribute to pathological immune cell survival exacerbating tissue damage. In cancers like lymphomas TOSO may help tumor cells escape apoptosis aiding in unchecked cell survival and tumor progression. The relationship between TOSO and disease highlights its potential as a therapeutic target alongside proteins like Bcl-2 which are also involved in cell survival and apoptosis regulation.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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All lanes: Western blot - Anti-TOSO antibody (ab168968) at 1 µg/mL
Lane 1: TOSO transfected 293T cell lysate at 15 µL
Lane 2: Non-transfected 293T cell lysate at 15 µL
All lanes: Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
Predicted band size: 43 kDa
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling TOSO with ab168968 at 3 μg/ml.
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