Rabbit Polyclonal TOX2 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TOX2 aa 50-200.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
ICC/IF | |
---|---|
Human | Tested |
Mouse | Predicted |
Rat | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.
C20orf100, GCX1, TOX2, TOX high mobility group box family member 2, Granulosa cell HMG box protein 1, GCX-1
Rabbit Polyclonal TOX2 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TOX2 aa 50-200.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
TOX2 also known as Thymocyte Selection-Associated High Mobility Group Box Protein 2 is a transcription factor weighing approximately 53 kDa. It is a nuclear protein expressed mainly in the T-cells of the thymus and spleen with notable expression in the brain and bone marrow. TOX2 belongs to the TOX family of proteins characterized by the presence of a high-mobility group (HMG) domain which facilitates its ability to bind and bend DNA thereby influencing the transcription of target genes.
TOX2 plays an important role in the development and function of the immune system. It assists in the maturation of T-cells and the differentiation of thymocytes being part of a complex transcriptional network. TOX2 interacts with other transcription factors to modulate gene expression profiles critical for immune responses. It has implications in regulating aspects of inflammation and peripheral tolerance indicating its influence on immune homeostasis.
TOX2 integrates into processes that govern T-cell receptor signaling and thymocyte development. It associates with pathways such as the Notch signaling pathway influencing thymocyte lineage decisions. Additionally TOX2 interacts with proteins like GATA3 and RUNX1 which are involved in the regulation of lymphoid cell development and differentiation further emphasizing its role in fine-tuning T-cell development and function.
Alterations in TOX2 expression or function bear connections to autoimmune conditions and certain cancers. Abnormal TOX2 activity has links to autoimmune diseases like systemic lupus erythematosus where it may exacerbate immune dysregulation. Its dysregulation also associates with T-cell lymphomas implicating proteins such as p53 in tumorigenic pathways where TOX2 might disrupt cell cycle control therefore influencing cancer progression.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Immunofluoresent analysis of PFA-fixed, Triton X-100 permeabilized A549 cells labeling TOX2 with ab220985 at 4 μg/ml (green).
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