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AB220985

Anti-TOX2 antibody

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(1 Publication)

Rabbit Polyclonal TOX2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TOX2 aa 50-200.

View Alternative Names

C20orf100, GCX1, TOX2, TOX high mobility group box family member 2, Granulosa cell HMG box protein 1, GCX-1

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-TOX2 antibody (AB220985)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TOX2 antibody (AB220985)

Immunofluoresent analysis of PFA-fixed, Triton X-100 permeabilized A549 cells labeling TOX2 with ab220985 at 4 μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TOX2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q96NM4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TOX2 also known as Thymocyte Selection-Associated High Mobility Group Box Protein 2 is a transcription factor weighing approximately 53 kDa. It is a nuclear protein expressed mainly in the T-cells of the thymus and spleen with notable expression in the brain and bone marrow. TOX2 belongs to the TOX family of proteins characterized by the presence of a high-mobility group (HMG) domain which facilitates its ability to bind and bend DNA thereby influencing the transcription of target genes.
Biological function summary

TOX2 plays an important role in the development and function of the immune system. It assists in the maturation of T-cells and the differentiation of thymocytes being part of a complex transcriptional network. TOX2 interacts with other transcription factors to modulate gene expression profiles critical for immune responses. It has implications in regulating aspects of inflammation and peripheral tolerance indicating its influence on immune homeostasis.

Pathways

TOX2 integrates into processes that govern T-cell receptor signaling and thymocyte development. It associates with pathways such as the Notch signaling pathway influencing thymocyte lineage decisions. Additionally TOX2 interacts with proteins like GATA3 and RUNX1 which are involved in the regulation of lymphoid cell development and differentiation further emphasizing its role in fine-tuning T-cell development and function.

Alterations in TOX2 expression or function bear connections to autoimmune conditions and certain cancers. Abnormal TOX2 activity has links to autoimmune diseases like systemic lupus erythematosus where it may exacerbate immune dysregulation. Its dysregulation also associates with T-cell lymphomas implicating proteins such as p53 in tumorigenic pathways where TOX2 might disrupt cell cycle control therefore influencing cancer progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.
See full target information TOX2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 47: PubMed33693954

2021

TGIF1 plays a carcinogenic role in esophageal squamous cell carcinoma through the Wnt/β‑catenin and Akt/mTOR signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Lingling Kong,Yang Yu,Hui Guan,Liyang Jiang,Fenghao Sun,Xiaolin Li,Wei Huang,Baosheng Li
View all publications
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