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AB272576

Anti-TOX4 antibody

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(1 Publication)

Rabbit Polyclonal TOX4 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TOX4 aa 450 to C-terminus.

View Alternative Names

C14orf92, KIAA0737, TOX4, TOX high mobility group box family member 4, Epidermal Langerhans cell protein LCP1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TOX4 antibody (AB272576)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TOX4 antibody (AB272576)

Paraffin-embedded formalin-fixed human urinary bladder tissue stained for TOX4 using ab272576 at 1/200 in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-TOX4 antibody (AB272576)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TOX4 antibody (AB272576)

PFA fixed, Triton X-100 permeabilized A431 (Human epidermoid carcinoma cell line) labeling TOX4 (green) using ab272576 at 2 ug/ml in ICC/IF analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TOX4 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O94842

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TOX4 also known as TOX high mobility group box family member 4 is a transcription factor with a molecular mass of approximately 80 kDa. It is a part of the TOX protein family and includes a conserved high-mobility group (HMG) box domain that allows it to bind DNA. TOX4 is expressed broadly in human tissues with particularly high levels seen in the brain and immune cells. Its expression pattern suggests a role in regulating genes involved in these tissues.
Biological function summary

TOX4 functions are important to transcriptional regulation processes where it interacts with other proteins. It takes part in forming a complex known as the PTW/PP1 complex which contributes to the regulation of chromatin structure and gene expression. Through its involvement in this complex TOX4 influences the cell cycle and DNA repair mechanisms. Studies indicate its role in modulating cellular responses to stress and controlling cell growth.

Pathways

TOX4 is involved in the Wnt signaling pathway and the DNA damage response pathway. Within the Wnt signaling pathway TOX4 impacts gene transcription that is vital for cellular development and differentiation. Notably it shares functional relationships with other proteins such as β-catenin. In the DNA damage response pathway TOX4 often interacts with p53 a protein key for maintaining genomic stability. Both these pathways highlight its importance in controlling cellular outcomes.

Researchers have linked TOX4 to conditions such as cancer and neurodegenerative diseases. Its role in DNA repair and gene transcription suggests that dysregulation of TOX4 may contribute to carcinogenesis possibly through interaction with aberrant p53. In neurodegenerative diseases like Alzheimer's alterations in TOX4 expression or function could associate with abnormal cell cycle control and neuronal cell death. Associations with amyloid precursor protein (APP) indicate a potential pathway through which TOX4 influences neurodegenerative disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed : 20516061). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation (By similarity).
See full target information TOX4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Neoplasma 70:534-544 PubMed37789777

2023

Migration-inducing gene-7 promotes glioma cell proliferation and invasiveness via activating the MAPK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhigang Pan,Chunhui Chen,Xinyue Huang,Yu Xiong,Xiaodong Kang,Jianfeng Zhou,Xiumei Guo,Shuni Zheng,Cui'e Wang,Feng Zheng,Weipeng Hu
View all publications
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