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AB138698

Anti-Toxoplasma gondii antibody

4

(1 Review)

|

(12 Publications)

Rabbit Polyclonal Toxoplasma gondii antibody. Suitable for ELISA, ICC/IF and reacts with Toxoplasma gondii samples. Cited in 12 publications. Immunogen corresponding to Cell preparation containing Toxoplasma gondii protein.

View Alternative Names

T. gondii

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Toxoplasma gondii

Applications

ELISA, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Toxoplasma gondii tachyzoites.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Toxoplasma gondii": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Concentration: 4–5 mg/mL (OD280nm, E0.1% = 1.4).
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
ab138698 is >95% pure as determined by SDS-PAGE.
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Toxoplasma gondii is a protozoan parasite with complex life cycles that include both sexual and asexual reproduction stages. Known also as T. gondii it has a mass around 98.3 kDa for its actin which plays an important role in its mobility and invasion of host cells. Toxoplasma gondii primarily targets feline hosts but it can infect most warm-blooded animals including humans. Expressed worldwide within cats and intermediate hosts the parasite distributes itself widely across diverse organisms.
Biological function summary

Toxoplasma gondii manipulates the host's immune response to survive and multiply. Within the host it exists as a complex of organelles called the apicoplast which is important for lipid synthesis and metabolism. The parasite modifies the host cells to create a protective environment by blocking host immune signaling pathways. It also affects host's cell apoptosis promoting the persistence of infection.

Pathways

Toxoplasma gondii integrates itself within both immune and metabolic pathways in the host. The parasite affects the NF-kB signaling pathway which influences host immune response allowing it to evade detection. It also interacts with host cell's cytokines like interleukin-12 (IL-12) and interferon-gamma (IFN-γ) which are proteins important for immune system modulation and control.

Toxoplasma gondii relates primarily to toxoplasmosis which can exhibit symptoms ranging from mild flu-like symptoms to severe neurological disorders and ocular disease. Pregnant women and immunocompromised individuals like those with HIV are at higher risk for complications from toxoplasmosis. The parasite links to proteins such as tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) which play roles in the inflammatory response and pathogenesis of the disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Toxoplasma gondii
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Publications (12)

Recent publications for all applications. Explore the full list and refine your search

Parasites & vectors 18:333 PubMed40760662

2025

Toxoplasma gondii-induced host's high secretion of 25-hydroxycholesterol for immunoprotection.

Applications

Unspecified application

Species

Unspecified reactive species

Zi-Han Yang,Wei-Ling Wu,Jia-Jia Zheng,Chi Zhang,Ying-Ying Lu,Hong-Juan Peng

Nature communications 16:3570 PubMed40240328

2025

GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspecies.

Applications

Unspecified application

Species

Unspecified reactive species

Francesca Torelli,Simon Butterworth,Eloise Lockyer,Ana N Matias,Franziska Hildebrandt,Ok-Ryul Song,Jennifer Pearson-Farr,Moritz Treeck

Biomolecules 15: PubMed40001505

2025

Activity Evaluation and Mode of Action of ICA Against In Vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Yanhua Qiu,Weiwei Wang,Qing Wang,Jing Xu,Guonian Dai,Yubin Bai,Jiyu Zhang

Parasites & vectors 18:56 PubMed39962518

2025

Effect of the flavonoid compound glabridin on tachyzoites and bradyzoites of Toxoplasma gondii.

Applications

Unspecified application

Species

Unspecified reactive species

Yanhua Qiu,Weiwei Wang,Qing Wang,Hongling Lin,Yubin Bai,Jiyu Zhang

Parasites & vectors 17:322 PubMed39080770

2024

Toxoplasma gondii bradyzoite-specific BAG1 is nonessential for cyst formation due to compensation by other heat-shock proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Weiling Wu,Qiqi Chen,Weihao Zou,Jiating Chen,Di Zhu,Huijing Yang,Lishan Ouyang,Xiaojun Liu,Hongjuan Peng

Nature microbiology 9:2051-2072 PubMed39075233

2024

Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Shahar Bracha,Hannah J Johnson,Nicole A Pranckevicius,Francesca Catto,Athena E Economides,Sergey Litvinov,Karoliina Hassi,Marco Tullio Rigoli,Cristina Cheroni,Matteo Bonfanti,Alessia Valenti,Sarah Stucchi,Shruti Attreya,Paul D Ross,Daniel Walsh,Nati Malachi,Hagay Livne,Reut Eshel,Vladislav Krupalnik,Doron Levin,Stuart Cobb,Petros Koumoutsakos,Nicolò Caporale,Giuseppe Testa,Adriano Aguzzi,Anita A Koshy,Lilach Sheiner,Oded Rechavi

International journal for parasitology. Drugs and drug resistance 25:100552 PubMed38986389

2024

In vitro and in vivo activity evaluation and mode of action of broxaldine on Toxoplasma gondii.

Applications

Unspecified application

Species

Unspecified reactive species

Yanhua Qiu,Bintao Zhai,Yubin Bai,Hongling Lin,Lingyu Wu,Wei Luo,Mengyan Shi,Shulin Chen,Jiyu Zhang

Parasites & vectors 16:454 PubMed38093309

2023

Lentinan has a beneficial effect on cognitive deficits induced by chronic Toxoplasma gondii infection in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Shuxi Liu,Ziyi Yan,Yuan Peng,Yunqiu Liu,Yiling Li,Daxiang Xu,Yuying Gong,Zeyu Cui,Yongshui Wu,Yumei Zhang,Dahui Wang,Wei Pan,Xiaoying Yang

mBio 14:e0183623 PubMed37675999

2023

An model of recrudescence reveals developmental plasticity of the bradyzoite stage.

Applications

Unspecified application

Species

Unspecified reactive species

Edward A Vizcarra,Amber L Goerner,Arzu Ulu,David D Hong,Kristina V Bergersen,Michael A Talavera,Karine Le Roch,Emma H Wilson,Michael W White

PLoS biology 21:e3002202 PubMed37459303

2023

A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells.

Applications

Unspecified application

Species

Unspecified reactive species

Eloise J Lockyer,Francesca Torelli,Simon Butterworth,Ok-Ryul Song,Steven Howell,Anne Weston,Philip East,Moritz Treeck
View all publications
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