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AB234860

Anti-TP53I11 antibody

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(3 Publications)

Rabbit Polyclonal TP53I11 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TP53I11 aa 1-50.

View Alternative Names

PIG11, TP53I11, Tumor protein p53-inducible protein 11, p53-induced gene 11 protein

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-TP53I11 antibody (AB234860)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TP53I11 antibody (AB234860)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling TP53I11 (green) using ab234860 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TP53I11 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

O14683

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TP53-induced protein 11 (TP53I11) also known as PIG11 is involved in p53-mediated cell signaling pathways. TP53I11 has a molecular weight of approximately 18 kDa. The protein predominantly expresses in tissues undergoing stress or DNA damage where it contributes to cellular responses such as cell cycle regulation and apoptosis. Through its association with p53 TP53I11 plays a part in sustaining cellular integrity by promoting the repair of damaged DNA or the elimination of cells when repair is not possible.
Biological function summary

TP53-induced protein 11 functions in pro-apoptotic pathways that safeguard cells against oncogenic transformation. It acts as a component of larger complexes engaged in cell cycle arrest and apoptosis induction. This protein participates in regulatory functions that determine cell fate emphasizing its involvement in preventing aberrant cell proliferation. TP53I11 collaborates with other p53 target genes to ensure the proper cellular outcomes under stress conditions.

Pathways

TP53I11 plays a significant role in the p53 signaling pathway and cell cycle control pathways. Within these pathways it interacts with p53 a critical tumor suppressor protein to promote cellular responses such as apoptosis. TP53I11 structurally and functionally links with other proteins like BAX involved in the execution of cell death processes thereby maintaining cellular homeostasis and preventing neoplastic growth.

TP53I11 show connections to cancer and neurodegenerative diseases. In many cancers mutations in p53 disrupt the regulation of TP53I11 leading to unchecked cell proliferation. The protein also associates with neurodegenerative processes as proper function is necessary to prevent neuronal death and maintain brain health. Related proteins including other p53-dependent proteins like PIG3 often share its role in these pathological conditions highlighting the importance of balanced TP53I11 activity in disease prevention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TP53I11
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 15: PubMed39858544

2025

Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination.

Applications

Unspecified application

Species

Unspecified reactive species

Colette B Rogers,Wendy Leung,Ryan M Baxley,Rachel E Kram,Liangjun Wang,Joseph P Buytendorp,Khoi Le,David A Largaespada,Eric A Hendrickson,Anja-Katrin Bielinsky

Heliyon 10:e29504 PubMed38655349

2024

An integrated analysis revealing the angiogenic function of TP53I11 in tumor microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Bai,Jun-Song Ren,Ke-Ran Li,Qin Jiang

European journal of histochemistry : EJH 66: PubMed36190397

2022

Overexpression of hsa_circ_0006470 inhibits the malignant behavior of gastric cancer cells <em>via</em> regulation of miR-1234/TP53I11 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jinbi Xie,Yong Ning,Lihang Zhang,Yuan Lin,Runsheng Guo,Shanjuan Wang
View all publications
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