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AB236887

Anti-TPPP2 antibody

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(2 Publications)

Rabbit Polyclonal TPPP2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TPPP2.

View Alternative Names

C14orf8, TPPP2, Tubulin polymerization-promoting protein family member 2, Protein p25-beta, TPPP/p18

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPPP2 antibody (AB236887)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPPP2 antibody (AB236887)

Paraffin-embedded human kidney tissue stained for TPPP2 using ab236887 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-TPPP2 antibody (AB236887)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TPPP2 antibody (AB236887)

MCF7 (human breast adenocarcinoma cell line) cells stained for TPPP2 (green) using ab236887 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPPP2 antibody (AB236887)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPPP2 antibody (AB236887)

Paraffin-embedded human liver cancer tissue stained for TPPP2 using ab236887 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-TPPP2 antibody (AB236887)
  • WB

Supplier Data

Western blot - Anti-TPPP2 antibody (AB236887)

All lanes:

Western blot - Anti-TPPP2 antibody (ab236887) at 1/500 dilution

All lanes:

Mouse gonadal tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 19 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TPPP2.

P59282

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TPPP2 also known as tubulin polymerization-promoting protein family member 2 is an important protein in the cellular microtubule network. It facilitates microtubule dynamics by promoting polymerization impacting cellular structure and mechanics. TPPP2 has a mass of approximately 22 kDa. Expression of TPPP2 is observed in various tissues though it is notably present in the nervous system where it plays a pivotal role in maintaining neuron architecture.
Biological function summary

This protein impacts cellular processes beyond microtubule stabilization. TPPP2 engages with other cytoskeletal proteins contributing to cell shape and motility. It does not typically form large protein complexes but interacts directly with tubulin forming a functional axis that modulates cytoskeleton behavior. The protein's involvement is essential for processes like mitosis and intracellular transport.

Pathways

The participation of TPPP2 in the microtubule-related pathways underpins its functional significance. It plays a role in the cytoskeleton organization and cell cycle regulation. The MAPK signaling pathway an important regulator of cellular responses to various stimuli shows connections to TPPP2. This protein has relationships with other key microtubule-associated proteins such as tau which also contribute to the dynamic regulation of microtubule networks.

TPPP2 implicates itself in neurodegenerative diseases like Parkinson's disease. Altered expression or mutation of TPPP2 can affect microtubule stability influencing disease progression. The protein's connection with tau is particularly relevant in Alzheimer's disease where tau dysfunction is a significant pathological feature. Studying TPPP2 provides insight into the molecular mechanisms underpinning these disorders and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable regulator of microtubule dynamics required for sperm motility (Probable). In contrast to other members of the family, has no microtubule bundling activity (PubMed : 17105200).
See full target information TPPP2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:5331 PubMed38909026

2024

TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Michał Brouze,Agnieszka Czarnocka-Cieciura,Olga Gewartowska,Monika Kusio-Kobiałka,Kamil Jachacy,Marcin Szpila,Bartosz Tarkowski,Jakub Gruchota,Paweł Krawczyk,Seweryn Mroczek,Ewa Borsuk,Andrzej Dziembowski

Translational oncology 22:101454 PubMed35617811

2022

Suppression of FAM83D Inhibits Glioma Proliferation, Invasion and Migration by Regulating the AKT/mTOR Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xia Li,Cui Sun,Jing Chen,Ji-Fen Ma,Yi-Heng Pan
View all publications
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