AB230788

Anti-TR1 antibody

Name: Anti-TR1 antibody (ab230788) | Abcam
Brand: Abcam Limited
SKU: AB230788

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(4 Publications)

Rabbit Polyclonal TR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TAS1R1.

View Alternative Names

GPR70, T1R1, TR1, GM148, TAS1R1, Taste receptor type 1 member 1, G-protein coupled receptor 70

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TR1 antibody (AB230788)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TR1 antibody (AB230788)

Formalin-fixed paraffin-embedded human non-small cell lung carcinoma tissue stained for TR1 with ab230788 at 6 μg/ml in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TR1 antibody (AB230788)

Formalin-fixed paraffin-embedded human testis tissue stained for TR1 with ab230788 at 6 μg/ml in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TR1 antibody (AB230788)

Formalin-fixed paraffin-embedded human colon carcinoma tissue stained for TR1 with ab230788 at 6 μg/ml in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TAS1R1. The exact immunogen used to generate this antibody is proprietary information.

Q7RTX1

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TAS1R2 (69%).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "6 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.099% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Thioredoxin reductase 1 (TR1) also known as TXNRD1 is an enzyme that is part of a family of pyridine nucleotide disulfide oxidoreductases. It catalyzes the reduction of thioredoxin using NADPH as an electron donor to maintain cellular redox balance. TR1 is a homodimeric protein with each subunit weighing approximately 55 kDa. It is found expressed in many tissues with higher levels noted in the liver kidney and testis reflecting its diverse cellular roles.

Biological function summary

TR1 influences cellular redox homeostasis and plays a significant role in regulating oxidative stress. It operates as a standalone enzyme not as part of a larger protein complex. By reducing disulfide bonds in proteins it helps to protect cells from oxidative damage and maintains the reduced state of cellular thiols. TR1 also contributes to the regulation of cell proliferation and apoptosis reflecting its multifaceted roles in both normal cellular processes and responses to cellular stress.

Pathways

TR1 takes part in both the oxidative stress response and the regulation of cellular metabolism. It is key within the thioredoxin system pathway working closely with thioredoxin (Trx) to detoxify reactive oxygen species. Additionally TR1 interacts with proteins such as Trx in the regulation of signaling pathways related to apoptosis. Together these interactions facilitate cellular responses to environmental changes.

TR1 displays significant roles in cancer and neurodegenerative diseases. It is frequently overexpressed in various cancer types which can contribute to tumor growth and resistance to therapies. The enzyme also shows connections to neurodegenerative disorders where imbalance in redox regulation and oxidative stress are common pathological features. In both contexts TR1 interacts closely with proteins like thioredoxin further emphasizing its critical place in disease pathogenesis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

See full target information TAS1R1

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 30:162 PubMed39333849

2024

CD9 promotes TβR2-TβR1 association driving the transition of human dermal fibroblasts to myofibroblast under hypoxia.

Applications

Unspecified application

Species

Unspecified reactive species

Wanqi Huang,Ze Zhang,Xin Li,Qingqing Zheng,Chao Wu,Luojia Liu,Ying Chen,Jiaping Zhang,Xupin Jiang

Animal science journal = Nihon chikusan Gakkaiho 93:e13754 PubMed35791780

2022

The expression of nutrient chemosensing gate molecules in the ileum and colon is altered for goats fed on a high-grain diet.

Applications

Unspecified application

Species

Unspecified reactive species

Changxin Tian,Jian Wu,Jinzhen Jiao,Chuanshe Zhou,Zhiliang Tan

Journal of agricultural and food chemistry 67:6809-6818 PubMed31134808

2019

Dietary Branched-Chain Amino Acids Regulate Food Intake Partly through Intestinal and Hypothalamic Amino Acid Receptors in Piglets.

Applications

Unspecified application

Species

Unspecified reactive species

Min Tian,Jinghui Heng,Hanqing Song,Kui Shi,Xiaofeng Lin,Fang Chen,Wutai Guan,Shihai Zhang

Food & function 10:3356-3367 PubMed31098606

2019

Branched chain amino acids stimulate gut satiety hormone cholecystokinin secretion through activation of the umami taste receptor T1R1/T1R3 using an in vitro porcine jejunum model.

Applications

Unspecified application

Species

Unspecified reactive species

Min Tian,Jinghui Heng,Hanqing Song,Yufeng Zhang,Fang Chen,Wutai Guan,Shihai Zhang

View all publications

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Product promise

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Anti-TR1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TR1 antibody (AB230788)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TR1 antibody (AB230788)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TR1 antibody (AB230788)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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