Rabbit Polyclonal TR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TAS1R1.
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Publications
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- Animal science journal = Nihon chikusan Gakkaiho 93:e137542022The expression of nutrient chemosensing gate molecules in the ileum and colon is altered for goats fed on a high-grain diet.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChangxin Tian,Jian Wu,Jinzhen Jiao,Chuanshe Zhou,Zhiliang TanPubMed 35791780
- Journal of agricultural and food chemistry 67:6809-68182019Dietary Branched-Chain Amino Acids Regulate Food Intake Partly through Intestinal and Hypothalamic Amino Acid Receptors in Piglets.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMin Tian et. al.PubMed 31134808
- Food & function 10:3356-33672019Branched chain amino acids stimulate gut satiety hormone cholecystokinin secretion through activation of the umami taste receptor T1R1/T1R3 using an in vitro porcine jejunum model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMin Tian,Jinghui Heng,Hanqing Song,Yufeng Zhang,Fang Chen,Wutai Guan,Shihai ZhangPubMed 31098606
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.099% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TAS1R1. The exact immunogen used to generate this antibody is proprietary information. Database link Q7RTX1
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Dog | Predicted |
| Hamster | Predicted |
| Horse | Predicted |
| Monkey | Predicted |
| Pig | Predicted |
| Rabbit | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 6 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Rabbit, Horse, Hamster, Dog, Pig, Monkey | Dilution info - | Notes - |
Target data
Function
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
Alternative names
GPR70, T1R1, TR1, GM148, TAS1R1, Taste receptor type 1 member 1, G-protein coupled receptor 70
Recommended products
Rabbit Polyclonal TR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TAS1R1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.099% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TAS1R1. The exact immunogen used to generate this antibody is proprietary information. Database link Q7RTX1
- Purification technique
- Affinity purification Immunogen
- Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TAS1R2 (69%).
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Thioredoxin reductase 1 (TR1) also known as TXNRD1 is an enzyme that is part of a family of pyridine nucleotide disulfide oxidoreductases. It catalyzes the reduction of thioredoxin using NADPH as an electron donor to maintain cellular redox balance. TR1 is a homodimeric protein with each subunit weighing approximately 55 kDa. It is found expressed in many tissues with higher levels noted in the liver kidney and testis reflecting its diverse cellular roles.
- Biological function summary
TR1 influences cellular redox homeostasis and plays a significant role in regulating oxidative stress. It operates as a standalone enzyme not as part of a larger protein complex. By reducing disulfide bonds in proteins it helps to protect cells from oxidative damage and maintains the reduced state of cellular thiols. TR1 also contributes to the regulation of cell proliferation and apoptosis reflecting its multifaceted roles in both normal cellular processes and responses to cellular stress.
- Pathways
TR1 takes part in both the oxidative stress response and the regulation of cellular metabolism. It is key within the thioredoxin system pathway working closely with thioredoxin (Trx) to detoxify reactive oxygen species. Additionally TR1 interacts with proteins such as Trx in the regulation of signaling pathways related to apoptosis. Together these interactions facilitate cellular responses to environmental changes.
- Associated diseases and disorders
TR1 displays significant roles in cancer and neurodegenerative diseases. It is frequently overexpressed in various cancer types which can contribute to tumor growth and resistance to therapies. The enzyme also shows connections to neurodegenerative disorders where imbalance in redox regulation and oxidative stress are common pathological features. In both contexts TR1 interacts closely with proteins like thioredoxin further emphasizing its critical place in disease pathogenesis.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TR1 antibody (ab230788)
Formalin-fixed paraffin-embedded human colon carcinoma tissue stained for TR1 with ab230788 at 6 μg/ml in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TR1 antibody (ab230788)
Formalin-fixed paraffin-embedded human non-small cell lung carcinoma tissue stained for TR1 with ab230788 at 6 μg/ml in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TR1 antibody (ab230788)
Formalin-fixed paraffin-embedded human testis tissue stained for TR1 with ab230788 at 6 μg/ml in immunohistochemical analysis.
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