Anti-TRAF3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TRAF3 also known as TNF receptor-associated factor 3 weighs approximately 63 kDa. This adaptor protein is expressed in many tissues including lymphoid organs and the spleen. Mechanically TRAF3 interacts with the tumor necrosis factor receptor (TNFR) superfamily serving as a pivotal mediator in transducing signals. The protein engages directly with cytoplasmic domains of receptors relaying information downstream to influence cellular responses.

Biological function summary

The protein TRAF3 influences immune response regulation and lymphocyte activation by being part of signaling complexes. It binds with other TRAF family members forming multimeric structures for modulating NF-kB and MAPK pathways. TRAF3 plays a role in both adaptive and innate immune mechanisms controlling cell survival signals and apoptosis. Its activity impacts B-cell and T-cell functions further emphasizing its role in immune cell dynamics.

Pathways

TRAF3 significantly impacts NF-kB activation and MAP kinase signaling. It cooperates with other proteins like TRAF2 and NIK to modulate these pathways. The NF-kB pathway important for immune and inflammatory responses involves TRAF3 in negatively regulating this pathway by targeting NIK for degradation. Similarly in the MAPK signaling TRAF3 influences response to environmental stresses.

Associated diseases and disorders

TRAF3 connects to conditions such as autoimmune diseases and lymphoma. In autoimmune diseases the improper function of TRAF3 affects immune tolerance leading to abnormal B-cell activity. In lymphomas TRAF3 mutations can result in loss of function contributing to the development of B-cell malignancies. Interactions with proteins like TRAF2 in these disorders illustrate its significance in pathology and potential targeting in therapeutic interventions.