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Rabbit Polyclonal TRAF3IP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TRAF3IP1 aa 1-250.

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Images

Western blot - Anti-TRAF3IP1 antibody - N-terminal (AB153860), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF3IP1 antibody - N-terminal (AB153860), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human TRAF3IP1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TDR0

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/1000.00000

Notes

Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).

Target data

Function

Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity).

Alternative names

Recommended products

Rabbit Polyclonal TRAF3IP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TRAF3IP1 aa 1-250.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human TRAF3IP1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TDR0
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TRAF3IP1 also known as Traf3-interacting protein 1 plays an important mechanical role in intracellular signaling. This protein is approximately 89 kDa in mass. TRAF3IP1 is involved in the regulation of membrane trafficking particularly in autophagy and endosomal sorting processes. It is commonly expressed in various tissues including the kidney liver and brain.

Biological function summary

TRAF3IP1 functions as an adaptor molecule in immune and cellular regulation. It is not only part of signaling pathways but also significant in the process of vesicle transport. TRAF3IP1 contributes to the assembly of protein complexes that are necessary for the effective sorting of endosomal cargo. Its interaction with members of the TRAF protein family supports signal transduction processes which are essential for cellular homeostasis.

Pathways

The function of TRAF3IP1 is significant in the NF-kappaB signaling pathway and the autophagy pathway. Within the NF-kappaB pathway TRAF3IP1 associations with proteins such as TRAF3 itself and TRAF6 help mediate immune responses. In the autophagy pathway TRAF3IP1 is involved with proteins like BECN1 (Beclin 1) contributing to the regulation of the autophagic process necessary for the removal of damaged cellular components.

Associated diseases and disorders

The dysfunction of TRAF3IP1 links to autoimmune diseases and neurodegenerative disorders. Aberrations in its expression or function have been connected to rheumatoid arthritis where it interacts with TRAF6 affecting inflammatory responses. Another related disorder is Alzheimer's disease where impaired autophagy involving Beclin 1 association highlights TRAF3IP1's important role in maintaining cellular integrity and preventing neurodegeneration.

Product promise

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2 product images

  • Western blot - Anti-TRAF3IP1 antibody - N-terminal (ab153860), expandable thumbnail

    Western blot - Anti-TRAF3IP1 antibody - N-terminal (ab153860)

    7.5% SDS PAGE

    All lanes: Western blot - Anti-TRAF3IP1 antibody - N-terminal (ab153860) at 1/3000 dilution

    All lanes: U87-MG whole cell lysate at 30 µg

    Predicted band size: 79 kDa, 94 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF3IP1 antibody - N-terminal (ab153860), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF3IP1 antibody - N-terminal (ab153860)

    Immunohistochemical analysis of paraffin-embedded H441 xenograft labeling TRAF3IP1 with ab153860 at 1/100 dilution.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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