Rabbit Polyclonal TRAF3IP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TRAF3IP1 aa 1-250.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
WB | IHC-P | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0). |
Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity).
IFT54, MIPT3, TRAF3IP1, TRAF3-interacting protein 1, Interleukin-13 receptor alpha 1-binding protein 1, Intraflagellar transport protein 54 homolog, Microtubule-interacting protein associated with TRAF3, MIP-T3
Rabbit Polyclonal TRAF3IP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TRAF3IP1 aa 1-250.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
TRAF3IP1 also known as Traf3-interacting protein 1 plays an important mechanical role in intracellular signaling. This protein is approximately 89 kDa in mass. TRAF3IP1 is involved in the regulation of membrane trafficking particularly in autophagy and endosomal sorting processes. It is commonly expressed in various tissues including the kidney liver and brain.
TRAF3IP1 functions as an adaptor molecule in immune and cellular regulation. It is not only part of signaling pathways but also significant in the process of vesicle transport. TRAF3IP1 contributes to the assembly of protein complexes that are necessary for the effective sorting of endosomal cargo. Its interaction with members of the TRAF protein family supports signal transduction processes which are essential for cellular homeostasis.
The function of TRAF3IP1 is significant in the NF-kappaB signaling pathway and the autophagy pathway. Within the NF-kappaB pathway TRAF3IP1 associations with proteins such as TRAF3 itself and TRAF6 help mediate immune responses. In the autophagy pathway TRAF3IP1 is involved with proteins like BECN1 (Beclin 1) contributing to the regulation of the autophagic process necessary for the removal of damaged cellular components.
The dysfunction of TRAF3IP1 links to autoimmune diseases and neurodegenerative disorders. Aberrations in its expression or function have been connected to rheumatoid arthritis where it interacts with TRAF6 affecting inflammatory responses. Another related disorder is Alzheimer's disease where impaired autophagy involving Beclin 1 association highlights TRAF3IP1's important role in maintaining cellular integrity and preventing neurodegeneration.
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7.5% SDS PAGE
All lanes: Western blot - Anti-TRAF3IP1 antibody - N-terminal (ab153860) at 1/3000 dilution
All lanes: U87-MG whole cell lysate at 30 µg
Predicted band size: 79 kDa, 94 kDa
Immunohistochemical analysis of paraffin-embedded H441 xenograft labeling TRAF3IP1 with ab153860 at 1/100 dilution.
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