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AB197665

Anti-TRAF3IP3 antibody

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(1 Publication)

Rabbit Polyclonal TRAF3IP3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Fusion protein corresponding to TRAF3IP3, fused to TRAF3IP3.

View Alternative Names

T3JAM, TRAF3IP3, TRAF3-interacting JNK-activating modulator, TRAF3-interacting protein 3

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF3IP3 antibody (AB197665)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF3IP3 antibody (AB197665)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling TRAF3IP3 using ab197665 at 1/25 dilution.

Western blot - Anti-TRAF3IP3 antibody (AB197665)
  • WB

Supplier Data

Western blot - Anti-TRAF3IP3 antibody (AB197665)

10% SDS-PAGE gel

All lanes:

Western blot - Anti-TRAF3IP3 antibody (ab197665) at 1/400 dilution

All lanes:

Jurkat cell lysate at 40 µg

Predicted band size: 64 kDa

false

Exposure time: 1s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Fusion protein corresponding to TRAF3IP3, fused to TRAF3IP3. The exact immunogen used to generate this antibody is proprietary information.

Q9Y228

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/15 - 1/50", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRAF3IP3 also known as T3JAM is a protein that interacts with tumor necrosis factor receptor-associated factors. It has a molecular weight of approximately 78 kDa. Researchers find TRAF3IP3 expressed mainly in lymphoid tissues as well as in different immune cells. This protein plays a role in various cellular processes by binding and influencing other proteins assisting in the modulation of immune system responses.
Biological function summary

TRAF3IP3 contributes to the regulation of immune signaling pathways. It participates in the formation of complex structures with other signaling molecules. By doing so it affects processes like the activation of T-cells and macrophages. The interactions within these complexes are essential for the propagation of immune signals impacting the body's ability to counter infections effectively.

Pathways

TRAF3IP3 is involved in pathways like the NF-kB signaling pathway and T-cell receptor signaling. In the context of the NF-kB pathway TRAF3IP3 works alongside other proteins such as TRAF3 to modulate the downstream effects that control immune and inflammatory responses. Through these pathways TRAF3IP3 is connected to different cellular responses that can help to maintain immune balance.

TRAF3IP3 is associated with autoimmune conditions and certain cancers. Its abnormal regulation can lead to the improper activation of immune responses contributing to the development of autoimmune diseases. Additionally alterations in the pathways involving TRAF3IP3 possibly in connection with proteins like TRAF3 and NF-kB can promote oncogenic processes linking it to specific types of cancer. Understanding its interactions could offer potential therapeutic targets for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed : 26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed : 26195727). Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed : 30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed : 30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed : 31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed : 32366851).
See full target information TRAF3IP3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 29:1258-68 PubMed24194321

2013

Chondrocyte-specific pathology during skeletal growth and therapeutics in a murine model of pseudoachondroplasia.

Applications

Unspecified application

Species

Unspecified reactive species

Karen L Posey,Francoise Coustry,Alka C Veerisetty,Peiman Liu,Joseph L Alcorn,Jacqueline T Hecht
View all publications
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