Rabbit Polyclonal TRAF5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRAF5 aa 1-200.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
WB | ICC/IF | |
---|---|---|
Human | Tested | Tested |
Cow | Predicted | Predicted |
Dog | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Cow, Dog | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Cow, Dog | Dilution info - | Notes - |
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
RNF84, RNF84, TRAF5, TNF receptor-associated factor 5, RING finger protein 84
Rabbit Polyclonal TRAF5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRAF5 aa 1-200.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
TRAF5 known as TNF receptor-associated factor 5 plays a role in cellular signaling pathways. This protein has a molecular mass of approximately 64 kDa. It is expressed in various tissues including lymphoid tissues and cells of the immune system. TRAF5 acts in signaling downstream of certain receptors like TNF receptor superfamily where it functions as an adapter protein that mediates signal transduction by interacting with other signaling molecules.
TRAF5 influences immune cell functions and inflammatory responses. It forms part of a larger protein complex that regulates the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Through this complex TRAF5 affects the transcription of genes involved in immune responses and cell survival. By modulating these processes TRAF5 helps maintain immune homeostasis and ensures proper immune response.
TRAF5 is involved in signaling pathways such as NF-κB and JNK (c-Jun N-terminal kinase) pathways. TRAF5 interacts with proteins like TRAF2 and RIPK1 to propagate signals that lead to activation of these pathways. NF-κB pathway regulates inflammation and immune responses while JNK pathway plays a part in stress responses and apoptosis. The interaction of TRAF5 with these proteins and pathways positions it as an integral part of the immune signaling network.
TRAF5 associates with autoimmune diseases including rheumatoid arthritis and lupus. Abnormal signaling through TRAF5 can lead to dysregulated immune responses contributing to these conditions. In rheumatoid arthritis for example TRAF5 may abnormally activate NF-κB pathway leading to enhanced inflammation. Moreover the interaction between TRAF5 and other proteins like TRAF1 influences the development of these diseases by affecting signal transduction which is important for understanding potential therapeutic targets in these disorders.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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7.5% SDS PAGE
All lanes: Western blot - Anti-TRAF5 antibody (ab137763) at 1/1000 dilution
All lanes: HeLa whole cell lysate at 30 µg
Predicted band size: 64 kDa
Immunofluorescence analysis of methanol fixed HeLa labeling TRAF5 with ab137763 at a 1/200 dilution.
The lower image was costained with Hoechst 33342.
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