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AB122283

Anti-TRANK1 antibody

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(1 Publication)

Rabbit Polyclonal TRANK1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRANK1 aa 900-1000.

View Alternative Names

KIAA0342, LBA1, TRANK1, TPR and ankyrin repeat-containing protein 1, Lupus brain antigen 1 homolog

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-TRANK1 antibody (AB122283)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TRANK1 antibody (AB122283)

Immunofluorescent staining of Human cell line U-2 OS shows positivity in nucleus but not nucleoli. Recommended concentration of ab122283 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRANK1 antibody (AB122283)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRANK1 antibody (AB122283)

ab122283, at a 1/200 dilution, staining TRANK1 in paraffin embedded Human fallopian tube by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRANK1 antibody (AB122283)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRANK1 antibody (AB122283)

ab122283, at a 1/200 dilution, staining TRANK1 in paraffin embedded Human duodenum tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TRANK1 aa 900-1000. The exact immunogen used to generate this antibody is proprietary information.

O15050

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRANK1 also known as Tetratricopeptide Repeat And Ankyrin Repeat Containing 1 is a protein with a mass of approximately 190 kDa. This protein features tetratricopeptide repeats which assist in protein-protein interactions. TRANK1 is expressed widely but higher levels appear in brain tissues. It plays roles in the regulation of several cellular processes through its binding capabilities acting as a modular unit that mediates various cellular interactions.
Biological function summary

Several cellular activities rely on TRANK1 due to its ability to participate in multiprotein complexes. It regulates transcription and cell cycle processes impacting how cells grow and respond to environmental signals. By modulating the activity of other proteins TRANK1 enables cells to maintain homeostasis and adapt to changes. These actions suggest a role in normal brain functions where regulatory precision is needed.

Pathways

The TRANK1 protein interacts within the Wnt signaling and stress response pathways. These pathways involve proteins that regulate gene expression in response to extracellular signals affecting cell fate and proliferation. In the Wnt signaling pathway TRANK1 can influence components like β-catenin impacting processes like cell differentiation. It ensures proper signaling flow affecting cellular responses and maintaining healthy cellular states.

TRANK1 links to psychiatric conditions specifically bipolar disorder and schizophrenia. Research indicates aberrant expression or mutations impair normal brain functionality potentially disrupting emotion regulation and cognitive abilities. TRANK1 associates with proteins like DISC1 which are implicated in brain development and psychiatric disorders suggesting its involvement in neuronal signaling or synaptic functions. Understanding TRANK1 function in these contexts may provide insights into novel therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TRANK1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Evolution; international journal of organic evolution 74:2451-2464 PubMed32989734

2020

Short-term heritable variation overwhelms 200 generations of mutational variance for metabolic traits in Caenorhabditis elegans.

Applications

Unspecified application

Species

Unspecified reactive species

Lindsay M Johnson,Olivia J Smith,Daniel A Hahn,Charles F Baer
View all publications
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Product promise

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