Anti-Transaldolase 1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Transaldolase 1 also known as TALDO1 or TAL-H is an enzyme that plays an important role in the pentose phosphate pathway by catalyzing the transfer of a three-carbon dihydroxyacetone unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate producing erythrose 4-phosphate and fructose 6-phosphate. The molecular mass of Transaldolase 1 is approximately 37 kDa. It is expressed in various tissues within the body with higher expression levels observed in the liver and adipose tissues.

Biological function summary

Transaldolase 1 regulates the balance between the oxidative and non-oxidative branches of the pentose phosphate pathway essential for nucleotide biosynthesis and maintaining cellular redox status. It functions independently not as part of a larger enzyme complex. The activity of this enzyme affects cellular metabolic functions impacting the synthesis of nucleotides and pentose sugars which are necessary for cell growth and division.

Pathways

Transaldolase 1 is integral to the pentose phosphate pathway also known as the hexose monophosphate shunt. This pathway is important for providing ribose-5-phosphate for nucleotide synthesis and NADPH for reductive biosynthesis and cellular antioxidant systems. It links with glycolysis through shared intermediates such as fructose 6-phosphate connecting with enzymes like glucose-6-phosphate dehydrogenase. This relationship allows cells to adjust their metabolic flux according to physiological needs.

Associated diseases and disorders

Transaldolase 1 mutations are associated with transaldolase deficiency a rare metabolic disorder that can lead to liver dysfunction and immunodeficiency. This deficiency affects the cellular ability to balance nucleotide and lipid biosynthesis contributing to the disease phenotype. There is also a connection with oxidative stress-related disorders as Transaldolase 1 indirectly influences reactive oxygen species via its role in NADPH production which ties it to proteins involved in oxidative stress responses like NADPH oxidase.