AB137629

Anti-Transaldolase 1 antibody

Name: Anti-Transaldolase 1 antibody (ab137629) | Abcam
Brand: Abcam Limited
SKU: AB137629
Price: 545 USD
Availability: InStock

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(5 Publications)

Rabbit Polyclonal Transaldolase 1 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TALDO1 aa 1-150.

View Alternative Names

TAL, TALDO, TALDOR, TALDO1, Transaldolase

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Transaldolase 1 antibody (AB137629)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Transaldolase 1 antibody (AB137629)

Immunohistochemical analysis of paraffin-embedded A549 xenograft labelling Transaldolase 1 using ab137629 at 1/100 dilution.

Supplier Data

Western blot - Anti-Transaldolase 1 antibody (AB137629)

10% SDS Page

All lanes:

Western blot - Anti-Transaldolase 1 antibody (ab137629) at 1/1000 dilution

All lanes:

A431 whole cells lysate at 30 µg

Predicted band size: 38 kDa

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Supplier Data

Western blot - Anti-Transaldolase 1 antibody (AB137629)

10% SDS Page

All lanes:

Western blot - Anti-Transaldolase 1 antibody (ab137629) at 1/1000 dilution

All lanes:

Mouse brain whole cells lysate at 50 µg

Predicted band size: 38 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TALDO1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

P37837

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Transaldolase 1 also known as TALDO1 or TAL-H is an enzyme that plays an important role in the pentose phosphate pathway by catalyzing the transfer of a three-carbon dihydroxyacetone unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate producing erythrose 4-phosphate and fructose 6-phosphate. The molecular mass of Transaldolase 1 is approximately 37 kDa. It is expressed in various tissues within the body with higher expression levels observed in the liver and adipose tissues.

Biological function summary

Transaldolase 1 regulates the balance between the oxidative and non-oxidative branches of the pentose phosphate pathway essential for nucleotide biosynthesis and maintaining cellular redox status. It functions independently not as part of a larger enzyme complex. The activity of this enzyme affects cellular metabolic functions impacting the synthesis of nucleotides and pentose sugars which are necessary for cell growth and division.

Pathways

Transaldolase 1 is integral to the pentose phosphate pathway also known as the hexose monophosphate shunt. This pathway is important for providing ribose-5-phosphate for nucleotide synthesis and NADPH for reductive biosynthesis and cellular antioxidant systems. It links with glycolysis through shared intermediates such as fructose 6-phosphate connecting with enzymes like glucose-6-phosphate dehydrogenase. This relationship allows cells to adjust their metabolic flux according to physiological needs.

Transaldolase 1 mutations are associated with transaldolase deficiency a rare metabolic disorder that can lead to liver dysfunction and immunodeficiency. This deficiency affects the cellular ability to balance nucleotide and lipid biosynthesis contributing to the disease phenotype. There is also a connection with oxidative stress-related disorders as Transaldolase 1 indirectly influences reactive oxygen species via its role in NADPH production which ties it to proteins involved in oxidative stress responses like NADPH oxidase.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed : 18687684, PubMed : 8955144). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity).

See full target information TALDO1

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:112510 PubMed40469112

2025

Multiomics reveal biomolecular shifts and ER stress in sleep-restricted women affecting NSC functions.

Applications

Unspecified application

Species

Unspecified reactive species

Vikas Malik,Xin Huang,Hongwei Zhou,Rebecca Bojar,Rajesh Kumar Soni,Donald W Landry,Sanja Jelic,Jianlong Wang

Oxidative medicine and cellular longevity 2022:3497644 PubMed35663205

2022

Myostatin Deficiency Enhances Antioxidant Capacity of Bovine Muscle via the SMAD-AMPK-G6PD Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Zhu,Xueqiao Wang,Zhuying Wei,Miaomiao Yang,Xinyu Zhou,Jiaru Lei,Chunling Bai,Guanghua Su,Xuefei Liu,Lei Yang,Guangpeng Li

Nature cell biology 24:148-154 PubMed35165416

2022

Metabolic determination of cell fate through selective inheritance of mitochondria.

Applications

Unspecified application

Species

Unspecified reactive species

Julia Döhla,Emilia Kuuluvainen,Nadja Gebert,Ana Amaral,Johanna I Englund,Swetha Gopalakrishnan,Svetlana Konovalova,Anni I Nieminen,Ella S Salminen,Rubén Torregrosa Muñumer,Kati Ahlqvist,Yang Yang,Hien Bui,Timo Otonkoski,Reijo Käkelä,Ville Hietakangas,Henna Tyynismaa,Alessandro Ori,Pekka Katajisto

Med (New York, N.Y.) 2:736-754 PubMed34223403

2021

Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathan M Ghergurovich,Jessica D Lang,Maren K Levin,Natalia Briones,Salvatore J Facista,Claudius Mueller,Alexis J Cowan,Matthew J McBride,Esther San Roman Rodriguez,Aaron Killian,Tuoc Dao,Jeffrey Lamont,Alison Barron,Xiaoyang Su,William P D Hendricks,Virginia Espina,Daniel D Von Hoff,Joyce O'Shaughnessy,Joshua D Rabinowitz

Cell metabolism 33:94-109.e8 PubMed33159852

2020

Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Zhang,Yi Xu,Wenyun Lu,Jonathan M Ghergurovich,Lili Guo,Ian A Blair,Joshua D Rabinowitz,Xiaolu Yang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Transaldolase 1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Transaldolase 1 antibody (AB137629)

Western blot - Anti-Transaldolase 1 antibody (AB137629)

Western blot - Anti-Transaldolase 1 antibody (AB137629)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

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