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AB151777

Anti-Transcription factor Sp4 antibody

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(3 Publications)

Rabbit Polyclonal Transcription factor Sp4 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Transcription factor Sp4.

View Alternative Names

Transcription factor Sp4, SPR-1, SP4

1 Images
Western blot - Anti-Transcription factor Sp4 antibody (AB151777)
  • WB

Unknown

Western blot - Anti-Transcription factor Sp4 antibody (AB151777)

All lanes:

Western blot - Anti-Transcription factor Sp4 antibody (ab151777) at 0.5 µg/mL

Lane 1:

Rat spleen tissue lysate

Lane 2:

HeLa cell lysate

Lane 3:

Jurkat cell lysate

Lane 4:

A549 Cell Lysate

Predicted band size: 82 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Transcription factor Sp4. The exact immunogen used to generate this antibody is proprietary information.

Q02446

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Transcription factor Sp4 also recognized as specificity protein 4 plays a pivotal role in regulating gene expression. Its molecular mass is approximately 80 kDa. This transcription factor belongs to the Sp family of zinc-finger DNA-binding proteins and can be found in various tissues with pronounced expression in the central nervous system. Sp4 binds to GC-rich motifs within promoter regions to regulate the transcription of specific target genes influencing cellular processes that contribute to development and function.
Biological function summary

The transcription factor influences the regulation of neuronal and neural-precursor development. Sp4 does not function as part of a stable complex but interacts dynamically with other transcriptional regulators enabling flexibility in gene expression control. Its activity affects the expression of genes critical for neuronal differentiation and synaptic plasticity mediating cellular responses fundamental to brain development and functioning.

Pathways

Sp4 participates significantly in the signaling associated with neurogenesis and synaptic transmission. It interacts within the Wnt signaling and cAMP response element-binding protein (CREB) pathways mediating cross-talk that underpins neuronal differentiation and survival. In these pathways Sp4 associates with related proteins such as Sp1 and Sp3 collectively modulating gene expression that drives neuronal processes.

Transcription factor Sp4 has been linked to psychiatric disorders and neurodegenerative diseases. Dysregulation of Sp4 expression is associated with schizophrenia and bipolar disorder where altered neuronal gene expression contributes to symptom development. In the context of these conditions Sp4 interacts with proteins such as BDNF (brain-derived neurotrophic factor) and GSK-3β (glycogen synthase kinase 3 beta) relating the transcription factor's role to pathways that are disrupted in mental health disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
See full target information Transcription factor Sp4
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

International journal of medical sciences 20:114-124 PubMed36619221

2023

EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically activating SP4 expression in the IL-6/sIL-6R signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Zhu,Haochen Guan,Xuan Wang,Yueyue Zhang,Lijie Gu,Jieshuang Jia,Ling Wang,Weijie Yuan

Cellular and molecular biology (Noisy-le-Grand, France) 68:161-166 PubMed37114256

2022

The FOXP4-AS1/miR-3130-3p/SP4 feedback loop is associated with prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Tingting Gu,Huafeng Pan,Fei Zhang,Li Wang,Zhongliang Cheng

Cell death & disease 9:497 PubMed29703892

2018

Interaction of the primordial germ cell-specific protein C2EIP with PTCH2 directs differentiation of embryonic stem cells via HH signaling activation.

Applications

Unspecified application

Species

Unspecified reactive species

Qisheng Zuo,Kai Jin,Jiuzhou Song,Yani Zhang,Guohong Chen,Bichun Li
View all publications
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Product promise

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