Anti-Transferrin Receptor 2/TFR2 antibody [EPR15322] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Transferrin Receptor 2 (TFR2) is a protein that facilitates iron uptake by binding to transferrin which is an iron-carrier protein in the blood. Also known as TFRC2 or CD71L2 it is a transmembrane glycoprotein with a molecular mass around 90 kDa. TFR2 is mainly expressed in the liver and erythroid cell precursors. It plays an important role in maintaining cellular iron homeostasis by mediating the endocytosis of transferrin-bound iron. Its expression can vary depending on the body’s iron levels and cellular type.

Biological function summary

TFR2 operates as an iron sensor and regulator influencing hepcidin expression a hormone critical for iron homeostasis. TFR2 is not part of any specific complex but interacts with several proteins such as HFE and TFR1 in iron sensing. It helps communicate the body’s iron status to the liver for the modulation of hepcidin levels. This balance ensures the regulation of systemic iron uptake and release which is essential for various physiological processes like erythropoiesis.

Pathways

TFR2 is involved prominently in the iron homeostasis pathway and the erythropoiesis pathway. In the iron homeostasis pathway it works alongside hepcidin to monitor and regulate iron levels in the body. The role it plays in erythropoiesis relates to its interaction with other iron-related proteins like TFR1 where it contributes to iron delivery necessary for red blood cell production. These pathways illustrate TFR2's importance in not only iron uptake but also the overall iron regulatory processes that sustain body function.

Associated diseases and disorders

Defects or mutations in TFR2 are connected to hereditary hemochromatosis which causes iron overload in tissues. Aberrant TFR2 function can disrupt the normal regulation of hepcidin leading to this iron accumulation. It also plays a role in anemia of chronic disease due to its influence on erythropoiesis through interactions with HFE and TFR1. These associations highlight the critical importance of TFR2 in both maintaining iron equilibrium and implicating it in iron-related pathologies.