Anti-Transportin-2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Transportin-2 also known as TNPO2 facilitates the import of proteins into the nucleus by recognizing nuclear localization signals. This protein plays an important role in nuclear-cytoplasmic transport. Transportin-2 weighs approximately 97 kDa and is mainly expressed in various tissues including the brain and testis. The protein functions as part of the karyopherin family which are important for nucleocytoplasmic transport.

Biological function summary

Transportin-2 mediates the translocation of certain RNA-binding proteins and unspliced viral RNA between the cytoplasm and the nucleus. The protein often associates with the importin-β family forming a complex for efficient cargo delivery to the nucleus. Its specificity and binding affinity for different proteins highlight its importance in cellular function especially in regulating protein traffic necessary for gene expression and viral replication processes.

Pathways

Transportin-2 participates in cellular transport and protein sorting pathways. It functions closely with proteins like RanGTP which regulates the directionality of nuclear import. Additionally Transportin-2 is a part of the nuclear import pathway where it maintains the nuclear-cytoplasmic balance of several other nuclear transport proteins.

Associated diseases and disorders

Transportin-2 links to several neurological disorders and some types of cancer. Alterations in its function and expression levels can affect protein import contributing to conditions like Huntington's disease due to disrupted nuclear transport processes. It also associates with proteins like Importin-α in mediating abnormal protein expression that might lead to cancerous growths. Understanding Transportin-2’s role in these diseases could offer insights for developing therapeutic advancements.