Anti-TRAP1 antibody [EPR5381]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TRAP1 also known as Tumor Necrosis Factor Receptor-Associated Protein 1 or Heat Shock Protein 75 (Hsp75) is a mitochondrial chaperone protein with a molecular weight of approximately 75 kDa. It functions to protect cells from stress-induced damage by ensuring proper protein folding and preventing aggregation within the mitochondria. TRAP1 is expressed across various tissues with higher levels observed in metabolically active organs such as the heart and liver. Its role extends to regulation of mitochondrial respiration and reactive oxygen species indicating its broad involvement in cellular homeostasis.

Biological function summary

This mitochondrial chaperone plays an important role in maintaining protein homeostasis within the cellular environment. It forms part of a complex with heat shock proteins coordinating cellular defense mechanisms against stress. TRAP1 interacts with other chaperones to stabilize proteins and assist in mitochondrial quality control. Its activities aid in reducing oxidative stress managing apoptosis and regulating mitochondrial dynamics. Through these functions TRAP1 supports cellular survival and metabolic adaptation under conditions of stress.

Pathways

TRAP1 is involved in the regulation of the mitochondrial apoptosis pathway and the oxidative stress response pathway. It interacts with proteins like cytochrome c and inhibitors of apoptosis proteins (IAPs) influencing the release of pro-apoptotic factors and modulation of survival signals. By modulating these pathways TRAP1 affects cellular energy production and stress responses impacting both cellular health and disease states.

Associated diseases and disorders

TRAP1 shows a direct link to cancer and neurodegenerative diseases. Overexpression of TRAP1 has been associated with various cancers where it promotes cell survival and resistance to apoptosis. In cancer cells TRAP1 interacts with proteins like p53 and Hsp90 contributing to the oncogenic process. In neurodegenerative disorders dysfunction of TRAP1 is linked to increased oxidative stress and mitochondrial dysfunction often relating to proteins such as PINK1 and Parkin which are important in the pathology of Parkinson’s disease.