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AB216593

Anti-TRAP80 antibody

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(1 Publication)

Rabbit Polyclonal TRAP80 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MED17 aa 150-250 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

ARC77, CRSP6, DRIP77, DRIP80, TRAP80, MED17, Mediator of RNA polymerase II transcription subunit 17, Activator-recruited cofactor 77 kDa component, Cofactor required for Sp1 transcriptional activation subunit 6, Mediator complex subunit 17, Thyroid hormone receptor-associated protein complex 80 kDa component, Transcriptional coactivator CRSP77, Vitamin D3 receptor-interacting protein complex 80 kDa component, CRSP complex subunit 6, Trap80

1 Images
Western blot - Anti-TRAP80 antibody (AB216593)
  • WB

Supplier Data

Western blot - Anti-TRAP80 antibody (AB216593)

All lanes:

Western blot - Anti-TRAP80 antibody (ab216593) at 1/300 dilution

All lanes:

mouse spleen lysate

Predicted band size: 73 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human MED17 aa 150-250 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9NVC6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRAP80 also known as Mediator complex subunit 13 (MED13) or Thyroid Hormone Receptor-Associated Protein 80 kDa (THRAP80) plays an essential role in transcription regulation. It is a part of the Mediator complex and has a molecular mass of approximately 80 kDa. TRAP80 functions as a bridge connecting transcriptional activators bound at enhancer regions to the RNA polymerase II machinery enabling transcription initiation. Expression of TRAP80 occurs in various human tissues including heart brain and liver where it mediates gene expression responsive to hormonal signals.
Biological function summary

TRAP80 is involved in regulating gene expression by modifying the chromatin structure which impacts transcription by making specific genes accessible or inaccessible to RNA polymerase II. As a part of the Mediator complex TRAP80 participates in facilitating interactions between enhancers and promoters influencing transcription rates. Through these actions TRAP80 impacts processes like cell growth differentiation and response to external signals and it maintains proper cellular function by regulating gene networks.

Pathways

TRAP80 notably engages in the Wnt signaling pathway and thyroid hormone signaling pathway where it helps modulate transcriptional responses by activating or repressing target genes. In the Wnt pathway TRAP80 works with beta-catenin an important mediator to regulate target gene expression linked with cellular proliferation and differentiation. In the thyroid hormone pathway TRAP80 works in concert with thyroid hormone receptors to mediate the biological effects of thyroid hormones influencing metabolism and development.

TRAP80 has associations with cancer and congenital heart defects. TRAP80's involvement in cancer relates to its role in misregulated transcription pathways that drive oncogenesis. It impacts cancers by facilitating mutations that change normal cell growth and differentiation signals. Additionally in congenital heart defects disturbances in the pathways involving TRAP80 can lead to improper cardiac development. MED13 as a part of the same complex has been studied in connection with these diseases highlighting the importance of the Mediator complex in disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
See full target information MED17
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Translational psychiatry 15:343 PubMed41022714

2025

Deep brain stimulation of medial forebrain bundle modulates noradrenergic activity and feedforward inhibition in rodent model of depression.

Applications

Unspecified application

Species

Unspecified reactive species

Zhuo Duan,Yixin Tong,Volker A Coenen,Máté D Döbrössy
View all publications
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Product promise

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