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AB235394

Anti-TRAPPC6B antibody

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(1 Publication)

Rabbit Polyclonal TRAPPC6B antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Trafficking protein particle complex subunit 6B aa 1-150.

View Alternative Names

Trafficking protein particle complex subunit 6B, TRAPP complex subunit 6B, TRAPPC6B

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAPPC6B antibody (AB235394)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAPPC6B antibody (AB235394)

Paraffin-embedded human adrenal gland tissue stained for TRAPPC6B with ab235394 (1/100 dilution) in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAPPC6B antibody (AB235394)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAPPC6B antibody (AB235394)

Paraffin-embedded human pancreas tissue stained for TRAPPC6B with ab235394 (1/100 dilution) in immunohistochemical analysis.

Western blot - Anti-TRAPPC6B antibody (AB235394)
  • WB

Supplier Data

Western blot - Anti-TRAPPC6B antibody (AB235394)

All lanes:

Western blot - Anti-TRAPPC6B antibody (ab235394) at 1/1000 dilution

All lanes:

Mouse kidney tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 18 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Trafficking protein particle complex subunit 6B aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q86SZ2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRAPPC6B also known as Trafficking Protein Particle Complex Subunit 6B is a component of the TRAPP complex which plays a role in vesicle-mediated transport within cells. TRAPPC6B is a protein with a molecular mass of approximately 16 kDa. It is expressed in various tissues including the liver kidney and brain indicating its broad involvement in cellular processes across different cell types.
Biological function summary

TRAPPC6B is involved in regulating intracellular trafficking particularly in the early steps of the secretory pathway. As part of the TRAPP complex it contributes to the tethering of COPII vesicles to Golgi membranes facilitating transport between the endoplasmic reticulum and Golgi apparatus. This action helps maintain cellular homeostasis and proper distribution of proteins and lipids within cells.

Pathways

TRAPPC6B is significant in the ER-Golgi transport pathway where it interacts with other subunits of the TRAPP complex including TRAPPC2 and TRAPPC3. These interactions are important for the assembly and function of the TRAPP complex in vesicle tethering. TRAPPC6B also plays a role in the macroautophagy pathway affecting the biogenesis of autophagosomes which are essential for cellular degradation and recycling processes.

TRAPPC6B has been implicated in neurodevelopmental disorders and is linked to intellectual disability. Mutations in TRAPPC6B can disrupt vesicle transport mechanisms leading to developmental delays and neurological symptoms. TRAPPC6B interacts with various proteins involved in these conditions like Sec23 and Sec24 which are subunits of the COPII coat. These interactions highlight the importance of TRAPPC6B in neurodevelopmental health and provide insights into possible therapeutic targets for related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (PubMed : 16025134, PubMed : 16828797). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable).
See full target information Trafficking protein particle complex subunit 6B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular cell 85:815-828.e10 PubMed39879985

2025

Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Carrillo Roas,Yuichi Yagita,Paul Murphy,Robert Kurzbauer,Tim Clausen,Eszter Zavodszky,Ramanujan S Hegde
View all publications
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Product promise

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