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AB217161

Anti-TREM1 antibody [RM0138-3C66] - Low endotoxin, Azide free

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(7 Publications)

Rat Monoclonal TREM1 antibody. Carrier free. Suitable for WB, IHC-Fr and reacts with Mouse samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Trem1.

View Alternative Names

CD354, Triggering receptor expressed on myeloid cells 1, TREM-1, Trem1

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

RM0138-3C66

Isotype

IgG2

Carrier free

Yes

Reacts with

Mouse

Applications

WB, IHC-Fr

applications

Immunogen

Recombinant Fragment Protein within Mouse Trem1. The exact immunogen used to generate this antibody is proprietary information.

Q9JKE2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with PBS at 200µL
Purification technique
Affinity purification Protein A
Purification notes
The IgG fraction of culture supernatant was purified by Protein A affinity chromatography.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Triggering receptor expressed on myeloid cells 1 (TREM1) is a transmembrane receptor involved in amplifying inflammatory responses. TREM1 is known alternatively as CD354. This protein has a molecular mass of approximately 30 kDa and is expressed on the surface of neutrophils monocytes and macrophages. The receptor participates in innate immune responses and acts as an amplifier for inflammatory signals. It is often found in tissues that are engaged in inflammatory processes including lungs and intestines.
Biological function summary

TREM1 significantly enhances the immune response by activating myeloid cells. It does not form a standalone unit; instead it works with the adapter protein DNAX-activating protein of 12 kDa (DAP12) which pairs with TREM1 to transduce signals that promote cytokine and chemokine release. Through this interaction the receptor plays a role in the defense against bacterial infection boosting the body's immune response during pathogen assault. This function positions TREM1 as an important player in the regulation of acute inflammation.

Pathways

TREM1 engages significantly in the Toll-like receptor (TLR) signaling pathway and NF-kB pathway. In these pathways TREM1 interacts with various proteins that include TLRs and DAP12 intensifying inflammatory responses. The integration of TREM1 within these pathways suggests that it acts as an important modulator of inflammation capable of enhancing TLR-mediated signals for a stronger immune response.

TREM1 connections extend to sepsis and inflammatory bowel disease (IBD). In the context of sepsis TREM1 expression correlates with increased inflammation and poor prognosis where it interacts with proteins involved in inflammatory pathways such as TNF-α. Concerning IBD TREM1's role in promoting inflammation links it to the pathogenesis of this disease where it could influence the severity and progression of IBD-related inflammation. Given these relationships therapeutic strategies targeting TREM1 could hold potential in modulating these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed : 23241959, PubMed : 27328755). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (By similarity).
See full target information Trem1
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:18 PubMed39809747

2025

Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson's disease model mice.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Song,Zi-Ming Zhou,Le-le Zhang,Hai-Feng Shu,Jin-Ru Xia,Xia Qin,Rong Hua,Yong-Mei Zhang

The journal of headache and pain 25:3 PubMed38177990

2024

Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-κB pathway in a chronic migraine model.

Applications

Unspecified application

Species

Unspecified reactive species

Songtang Sun,Zhenzhen Fan,Xuejiao Liu,Longde Wang,Zhaoming Ge

Neural regeneration research 19:1375-1384 PubMed37905888

2023

TREM-1 mediates interaction between substantia nigra microglia and peripheral neutrophils.

Applications

Unspecified application

Species

Unspecified reactive species

Tong Shen,Guiyun Cui,Hao Chen,Long Huang,Wei Song,Jie Zu,Wei Zhang,Chuanying Xu,Liguo Dong,Yongmei Zhang

Frontiers in bioengineering and biotechnology 10:973588 PubMed36110326

2022

Synergistic effect of GF9 and streptomycin on relieving gram-negative bacteria-induced sepsis.

Applications

Unspecified application

Species

Unspecified reactive species

Bing Wei,Yingmin Ma

Frontiers in immunology 12:766178 PubMed34721438

2021

TREM1 Regulates Neuroinflammatory Injury by Modulate Proinflammatory Subtype Transition of Microglia and Formation of Neutrophil Extracellular Traps Interaction With SYK in Experimental Subarachnoid Hemorrhage.

Applications

Unspecified application

Species

Unspecified reactive species

Xinyan Wu,Hanhai Zeng,Chaoran Xu,Huaijun Chen,Linfeng Fan,Hang Zhou,Qian Yu,Xiongjie Fu,Yucong Peng,Feng Yan,Xiaobo Yu,Gao Chen

Translational stroke research : PubMed32862402

2020

TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage.

Applications

Unspecified application

Species

Unspecified reactive species

Pengfei Xu,Ye Hong,Yi Xie,Kang Yuan,Juanji Li,Rui Sun,Xiaohao Zhang,Xiaolei Shi,Rongrong Li,Jiaonan Wu,Xinfeng Liu,Wei Hu,Wen Sun

Cell death & disease 10:555 PubMed31324751

2019

Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Pengfei Xu,Xiaohao Zhang,Qian Liu,Yi Xie,Xiaolei Shi,Jingjing Chen,Yunzi Li,Hongquan Guo,Rui Sun,Ye Hong,Xinfeng Liu,Gelin Xu
View all publications
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