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AB20923

Anti-Treponema pallidum antibody

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(6 Publications)

Rabbit Polyclonal Treponema pallidum antibody. Suitable for IHC-P, ICC/IF and reacts with Treponema pallidum samples. Cited in 6 publications.

View Alternative Names

T. pallidum

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Treponema pallidum antibody (AB20923)
  • IHC-P

PubMed

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Treponema pallidum antibody (AB20923)

Immunohistochemical analysis of HIV-infected syphilitic skin tissue, staining Treponema pallidum with ab20923.

Antigen retrieval was performed before blocking with normal horse serum and 2% BSA. Samples were incubated with primary antibody overnight at 4°C. A biotinylated horse anti-rabbit IgG was used as the secondary antibody. Staining was detected using AEC.

Image from Stary G et al., The American Journal of Pathology, Volume 177, Issue 5, November 2010, Pages 2421–2432. Fig 7.; doi: 10.2353/ajpath.2010.100277. Epub 2010 Oct 1. with permission from Elsevier.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Treponema pallidum

Applications

IHC-P, ICC/IF

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Treponema pallidum": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/3000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
>95% pure. Sodium sulfate precipitation and DEAE chromatography.
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Treponema pallidum also known as T. pallidum is a spirochete bacterium responsible for syphilis. It is a pathogen with a mass of approximately 1000 to 1500 kilodaltons. This bacterium expresses itself through a complex outer membrane rich in lipoproteins which allows it to evade the host immune response. Treponema pallidum resides primarily in various human tissues and fluids particularly the bloodstream where it can disseminate throughout the body.
Biological function summary

The spirochete bacterium causes systemic infection and can invade multiple organs and systems. As part of a highly invasive entity Treponema pallidum can penetrate the endothelium and interact with host cells promoting persistent infection. It lacks numerous enzymes found in other bacteria which makes it dependent on the host for nutrients complicating its study. The bacterium is adept at avoiding the immune system partly due to its limited surface proteins that are targeted by host defenses.

Pathways

The interaction of Treponema pallidum with host immune pathways involves critical interference with host-pathogen interactions. It affects pathways related to immune evasion influencing the complement system and cytokine signaling. The bacterium influences other proteins like those regulating immune responses resulting in altered host immune functionalities. It exploits these pathways to promote survival and successful infection within the host.

Treponema pallidum causes syphilis a chronic disease characterized by multiple clinical stages including primary secondary and tertiary syphilis. It also has associations with neurosyphilis which affects the nervous system. Treponema pallidum's involvement with these conditions often relates to immune response alterations and inflammation mediated through its impact on proteins involved in immune signaling and neurological systems. Understanding these interactions can facilitate development of effective treatments or preventive measures.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Treponema pallidum
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 20:e1012483 PubMed39226326

2024

Phosphorylated vimentin-triggered fibronectin matrix disaggregation enhances the dissemination of Treponema pallidum subsp. pallidum across the microvascular endothelial barrier.

Applications

Unspecified application

Species

Unspecified reactive species

Xi Luo,Litian Zhang,Xiaoyuan Xie,Liyan Yuan,Yanqiang Shi,Yinbo Jiang,Wujian Ke,Bin Yang

Journal of the European Academy of Dermatology and Venereology : JEADV 38:1166-1178 PubMed38258964

2024

Treponema pallidum protein Tp47 induced prostaglandin E2 to inhibit the phagocytosis in human macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

D-Y Yi,Q-Y Xu,Y He,X-Q Zheng,T-C Yang,Y Lin

International journal of clinical and experimental 8:15479-88 PubMed26823918

2015

Development of a new real-time PCR system for simultaneous detection of bacteria and fungi in pathological samples.

Applications

Unspecified application

Species

Unspecified reactive species

Hitomi Fukumoto,Yuko Sato,Hideki Hasegawa,Hidehisa Saeki,Harutaka Katano

Acta dermato-venereologica 94:617-8 PubMed24448719

2014

Primary syphilis presenting as bilateral nipple-areola eczematoid lesions.

Applications

Unspecified application

Species

Unspecified reactive species

Song Zheng,Jia Liu,Xue-Gang Xu,Xing-Hua Gao,Hong-Duo Chen

The American journal of pathology 177:2421-32 PubMed20889558

2010

Host defense mechanisms in secondary syphilitic lesions: a role for IFN-gamma-/IL-17-producing CD8+ T cells?

Applications

IHC-P

Species

Unspecified reactive species

Georg Stary,Irene Klein,Marie-Charlotte Brüggen,Sabine Kohlhofer,Patrick M Brunner,Daniel Spazierer,Leonhard Müllauer,Peter Petzelbauer,Georg Stingl

Gut 57:1331-3 PubMed18719143

2008

In vivo diagnosis of intestinal spirochaetosis by confocal endomicroscopy.

Applications

Unspecified application

Species

Unspecified reactive species

U Günther,H-J Epple,F Heller,C Loddenkemper,M Grünbaum,T Schneider,M Zeitz,C Bojarski
View all publications
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