Anti-TREX2 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The TREX2 protein plays a significant role in DNA repair mechanisms. It belongs to the exonuclease family and contributes to maintaining DNA stability especially under conditions of stress and DNA damage. TREX2 functions as part of DNA repair complexes that detect and process damaged DNA highlighting its importance in genomic safeguarding. Its exonuclease activity primarily aids in clearing path for repair polymerases during synthesis.

Pathways

Studies have shown that TREX2 influences the DNA repair pathway by interacting with components involved in homologous recombination and non-homologous end-joining. It works closely with protein partners like RAD51 and Ku70/80 to successfully complete DNA repair processes. TREX2's exonuclease activity helps in the initial end processing that is important in both pathways therefore facilitating accurate DNA repair and preventing mutations.