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AB83893

Anti-TREX2 antibody

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(2 Publications)

Rabbit Polyclonal TREX2 antibody. Suitable for WB and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TREX2.

View Alternative Names

Three prime repair exonuclease 2, 3'-5' exonuclease TREX2, TREX2

1 Images
Western blot - Anti-TREX2 antibody (AB83893)
  • WB

Unknown

Western blot - Anti-TREX2 antibody (AB83893)

All lanes:

Western blot - Anti-TREX2 antibody (ab83893) at 2.5 µg/mL

All lanes:

rat liver tissue lysate at 15 µg

Secondary

All lanes:

anti-rabbit secondary

Predicted band size: 30 kDa

Observed band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TREX2. The exact immunogen used to generate this antibody is proprietary information.

Q9BQ50

Specificity

This antibody will not cross-react with the related protein TREX1.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2-4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TREX2 protein also known as the Three Prime Repair Exonuclease 2 functions as a DNA exonuclease involved in the repair of double-stranded DNA breaks. It has a molecular mass of approximately 31 kDa. This protein specializes in the removal of mismatched nucleotides in a 3' to 5' direction facilitating the maintenance of genomic integrity. TREX2 is mainly expressed in the skin thymus and testes suggesting a role in rapidly dividing tissues with high exposure to environmental stress.
Biological function summary

The TREX2 protein plays a significant role in DNA repair mechanisms. It belongs to the exonuclease family and contributes to maintaining DNA stability especially under conditions of stress and DNA damage. TREX2 functions as part of DNA repair complexes that detect and process damaged DNA highlighting its importance in genomic safeguarding. Its exonuclease activity primarily aids in clearing path for repair polymerases during synthesis.

Pathways

Studies have shown that TREX2 influences the DNA repair pathway by interacting with components involved in homologous recombination and non-homologous end-joining. It works closely with protein partners like RAD51 and Ku70/80 to successfully complete DNA repair processes. TREX2's exonuclease activity helps in the initial end processing that is important in both pathways therefore facilitating accurate DNA repair and preventing mutations.

TREX2 has been associated with conditions like skin carcinomas and immune system disorders. Aberrant activity or expression of TREX2 usually leads to increased genomic instability which is a hallmark of cancer development. In skin carcinomas its interaction with other DNA repair proteins like p53 might influence tumorigenesis. Also improper TREX2 function in immune cells links it to potential immune system dysregulation affecting processes such as inflammation and autoimmunity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair.
See full target information TREX2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 10: PubMed39589791

2024

Role of cGAS/STING pathway in aging and sexual dimorphism in diabetic kidney disease.

Applications

Unspecified application

Species

Unspecified reactive species

Sherif Khedr,Lashodya V Dissanayake,Ammar J Alsheikh,Adrian Zietara,Denisha R Spires,Romica Kerketta,Angela J Mathison,Raul Urrutia,Oleg Palygin,Alexander Staruschenko

Science immunology 8:eade1167 PubMed36961908

2023

DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Hao,Chuanzong Zhan,Chaoyang Lian,Simin Luo,Wenyi Cao,Binbin Wang,Xia Xie,Xiaofei Ye,Tuantuan Gui,Claudia Voena,Chiara Pighi,Yanyan Wang,Ying Tian,Xin Wang,Pengfei Dai,Yanni Cai,Xiaojing Liu,Shengqun Ouyang,Shiqi Sun,Qianwen Hu,Jun Liu,Youqiong Ye,Jingkun Zhao,Aiguo Lu,Ji-Yang Wang,Chuanxin Huang,Bing Su,Fei-Long Meng,Roberto Chiarle,Qiang Pan-Hammarström,Leng-Siew Yeap
View all publications
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