AB204119

Anti-TRIB2 antibody

Name: Anti-TRIB2 antibody (ab204119) | Abcam
Brand: Abcam Limited
SKU: AB204119

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(1 Publication)

Rabbit Polyclonal TRIB2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TRIB2 aa 150-250 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

TRB2, TRIB2, Tribbles homolog 2, TRB-2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIB2 antibody (AB204119)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIB2 antibody (AB204119)

Immunohistochemical analysis of formalin-fixed paraffin-embedded Human lung cancer tissue labeling TRIB2 with ab204119 at 1/200, followed by conjugation to the secondary antibody and DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIB2 antibody (AB204119)

Immunohistochemical analysis of formalin-fixed paraffin-embedded Human lung cancer tissue labeling TRIB2 with ab204119 at 1/200, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TRIB2 aa 150-250 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q92519

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>(or 1/50 - 1/200 if using a fluorescent secondary antibody)</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRIB2 also known as Tribbles homolog 2 is a protein involved in various cellular processes. With a molecular weight of approximately 39 kDa TRIB2 acts as a pseudokinase meaning it lacks catalytic activity but can influence other kinases' function. Researchers found TRIB2 expression in several tissues including the liver lung and immune cells. This protein plays a role in regulating cell proliferation differentiation and apoptosis through its interactions with various signaling pathways and molecules.

Biological function summary

TRIB2 influences cell survival and immune responses. It does not operate alone but forms a part of larger protein complexes to exert its effects. By interacting with transcription factors and other signaling molecules TRIB2 modulates gene expression affecting cell destiny. Though it lacks inherent enzymatic activity TRIB2 can serve as a scaffold or adaptor anchoring other molecules together which significantly shapes cellular dynamics.

Pathways

TRIB2 interacts with several key signaling systems that regulate cell behavior. One notable pathway is the MAPK (Mitogen-Activated Protein Kinase) pathway where TRIB2 affects downstream signaling events that are important for cell growth and response to stress. Additionally TRIB2 engages with the PI3K/AKT pathway a critical mediator of cell survival and metabolism. Within these pathways TRIB2 aligns with or modulates proteins such as AKT and ERK further integrating its role in cellular communication networks.

Researchers have linked TRIB2 to cancer and autoimmune conditions. In the context of cancer elevated TRIB2 levels have been observed in certain leukemias and melanoma where it might promote oncogenic pathways via proteins like C/EBPα or NF-κB. In autoimmune disorders aberrant TRIB2 expression can disrupt immune cell function potentially enhancing inflammatory processes. The protein may indirectly cause shifts in immune tolerance suggesting its involvement in diseases such as rheumatoid arthritis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).

See full target information TRIB2

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell biology international 48:626-637 PubMed38263609

2024

LRP8 promotes tumorigenesis in ovarian cancer through inhibiting p53 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Xu,Yang Zhou,Xiling Yi,Xiaocui Nie

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TRIB2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIB2 antibody (AB204119)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIB2 antibody (AB204119)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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