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AB272544

Anti-TRIB2 antibody

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(2 Publications)

Rabbit Polyclonal TRIB2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIB2 aa 1-150.

View Alternative Names

TRB2, TRIB2, Tribbles homolog 2, TRB-2

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-TRIB2 antibody (AB272544)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TRIB2 antibody (AB272544)

PFA fixed, Triton X-100 permeablized A-431 cells (human epidermoid carcinoma cell line) labeling TRIB2 (green) using ab272544 at 2 ug/ml in ICC/IF analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TRIB2 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q92519

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Dog": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRIB2 also known as Tribbles homolog 2 is a protein involved in various cellular processes. With a molecular weight of approximately 39 kDa TRIB2 acts as a pseudokinase meaning it lacks catalytic activity but can influence other kinases' function. Researchers found TRIB2 expression in several tissues including the liver lung and immune cells. This protein plays a role in regulating cell proliferation differentiation and apoptosis through its interactions with various signaling pathways and molecules.
Biological function summary

TRIB2 influences cell survival and immune responses. It does not operate alone but forms a part of larger protein complexes to exert its effects. By interacting with transcription factors and other signaling molecules TRIB2 modulates gene expression affecting cell destiny. Though it lacks inherent enzymatic activity TRIB2 can serve as a scaffold or adaptor anchoring other molecules together which significantly shapes cellular dynamics.

Pathways

TRIB2 interacts with several key signaling systems that regulate cell behavior. One notable pathway is the MAPK (Mitogen-Activated Protein Kinase) pathway where TRIB2 affects downstream signaling events that are important for cell growth and response to stress. Additionally TRIB2 engages with the PI3K/AKT pathway a critical mediator of cell survival and metabolism. Within these pathways TRIB2 aligns with or modulates proteins such as AKT and ERK further integrating its role in cellular communication networks.

Researchers have linked TRIB2 to cancer and autoimmune conditions. In the context of cancer elevated TRIB2 levels have been observed in certain leukemias and melanoma where it might promote oncogenic pathways via proteins like C/EBPα or NF-κB. In autoimmune disorders aberrant TRIB2 expression can disrupt immune cell function potentially enhancing inflammatory processes. The protein may indirectly cause shifts in immune tolerance suggesting its involvement in diseases such as rheumatoid arthritis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).
See full target information TRIB2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of oncology 60: PubMed35302171

2022

TRIB2 regulates the expression of miR‑33a‑5p through the ERK/c‑Fos pathway to affect the imatinib resistance of chronic myeloid leukemia cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hang Sun,Youjie Li,Xiao Wang,Xue Zhou,Simin Rong,Dongmin Liang,Guangbin Sun,Huizhen Cao,Hongfang Sun,Ranran Wang,Yunfei Yan,Shuyang Xie,Yunxiao Sun

Cancer cell international 22:42 PubMed35090460

2022

miR-199b-3p contributes to acquired resistance to cetuximab in colorectal cancer by targeting CRIM1 via Wnt/β-catenin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Hu Han,Yan Li,Wan Qin,Lu Wang,Han Yin,Beibei Su,Xianglin Yuan
View all publications
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Product promise

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