Anti-TRIC-B antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TRIC-B also known as TMEM38B serves as an important potassium ion channel present in the sarcoplasmic and endoplasmic reticulum membranes. This protein weighs approximately 38 kDa and facilitates the release of K+ ions across these membranes which helps to maintain ion homeostasis. It is widely expressed with higher presence noted in muscle tissue and cardiac cells thereby supporting the essential regulation of electrochemical gradients in these areas.

Biological function summary

The TRIC-B ion channel regulates cellular membrane potential and influences calcium handling. It often functions as part of a complex with other ion channels coordinating changes in muscle contraction and relaxation. This coordination is necessary for processes like heartbeat regulation where proper ion channel function allows for rhythmic contraction of the heart muscles.

Pathways

TRIC-B plays a significant role in the calcium signaling pathway which is essential for muscle contraction and is also involved in the cardiac action potential pathway. It interacts closely with other proteins such as RyR (ryanodine receptor) and SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase) both of which are critical in managing calcium flux within the cells. TRIC-B's role ensures the balance and flow of ions required for proper physiological responses.

Associated diseases and disorders

Mutations or dysfunctions in TRIC-B can cause significant conditions such as hypertension and skeletal muscle myopathy. Through its interaction with RyR TRIC-B is linked to muscle disorders where improper calcium release affects cell function and health. Understanding these connections aids in the development of targeted therapies and treatments for related conditions.