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AB106401

Anti-TRIC-B antibody

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(1 Publication)

Rabbit Polyclonal TRIC-B antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMEM38B.

View Alternative Names

C9orf87, TRICB, TMEM38B, Trimeric intracellular cation channel type B, TRIC-B, Transmembrane protein 38B

1 Images
Western blot - Anti-TRIC-B antibody (AB106401)
  • WB

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Western blot - Anti-TRIC-B antibody (AB106401)

Lane 1:

Western blot - Anti-TRIC-B antibody (ab106401) at 1 µg/mL

Lane 2:

Western blot - Anti-TRIC-B antibody (ab106401) at 2 µg/mL

All lanes:

Rat thymus tissue lysate at 15 µg

Predicted band size: 28 kDa,29 kDa,32 kDa,39 kDa,97 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TMEM38B. The exact immunogen used to generate this antibody is proprietary information.

Q9NVV0

Specificity

ab106401 will not cross-react with TMEM38A.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRIC-B also known as TMEM38B serves as an important potassium ion channel present in the sarcoplasmic and endoplasmic reticulum membranes. This protein weighs approximately 38 kDa and facilitates the release of K+ ions across these membranes which helps to maintain ion homeostasis. It is widely expressed with higher presence noted in muscle tissue and cardiac cells thereby supporting the essential regulation of electrochemical gradients in these areas.
Biological function summary

The TRIC-B ion channel regulates cellular membrane potential and influences calcium handling. It often functions as part of a complex with other ion channels coordinating changes in muscle contraction and relaxation. This coordination is necessary for processes like heartbeat regulation where proper ion channel function allows for rhythmic contraction of the heart muscles.

Pathways

TRIC-B plays a significant role in the calcium signaling pathway which is essential for muscle contraction and is also involved in the cardiac action potential pathway. It interacts closely with other proteins such as RyR (ryanodine receptor) and SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase) both of which are critical in managing calcium flux within the cells. TRIC-B's role ensures the balance and flow of ions required for proper physiological responses.

Mutations or dysfunctions in TRIC-B can cause significant conditions such as hypertension and skeletal muscle myopathy. Through its interaction with RyR TRIC-B is linked to muscle disorders where improper calcium release affects cell function and health. Understanding these connections aids in the development of targeted therapies and treatments for related conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). Activated by increased cytosolic Ca(2+) levels (By similarity).
See full target information TMEM38B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 42:111949 PubMed36640307

2023

Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates.

Applications

Unspecified application

Species

Unspecified reactive species

Nathalie Scrima,Romain Le Bars,Quentin Nevers,Damien Glon,Guillaume Chevreux,Ahmet Civas,Danielle Blondel,Cécile Lagaudrière-Gesbert,Yves Gaudin
View all publications
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Product promise

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