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Rabbit Polyclonal TRIM10 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM10 aa 1-300.

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Images

Immunocytochemistry/ Immunofluorescence - Anti-TRIM10 antibody (AB151306), expandable thumbnail
  • Western blot - Anti-TRIM10 antibody (AB151306), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human TRIM10 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UDY6

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBICC/IF
Human
Tested
Tested
Monkey
Predicted
Predicted

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Predicted
Predicted

Species

Monkey

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/1000.00000

Notes

-

Predicted
Predicted

Species

Monkey

Dilution info

-

Notes

-

Target data

Function

E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647).

Alternative names

Recommended products

Rabbit Polyclonal TRIM10 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM10 aa 1-300.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human TRIM10 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UDY6
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TRIM10 also known as Tripartite Motif Containing 10 is a protein that belongs to the TRIM family characterized by its tripartite motif which includes a RING finger one or two B-box domains and a coiled-coil region. It has an approximate molecular mass of 60 kDa. TRIM10 expresses mainly in hematopoietic tissues such as the bone marrow and various cell types within the immune system. Its structure suggests a role in protein-protein interactions particularly those involved with ubiquitination processes.

Biological function summary

TRIM10 participates in immune response modulation and iron homeostasis. Within biological systems it seems to play a part in a protein complex that influences the cytoskeleton's organization and cellular trafficking. TRIM10 supports erythropoiesis facilitating the maturation and differentiation of erythroid cells in the bone marrow. This involvement highlights its influence in maintaining effective functional condition of red blood cell populations.

Pathways

TRIM10 participates in the ubiquitin-proteasome pathway which controls the degradation of proteins and is important for regulating protein levels and function in cells. It engages particularly within the heme biosynthesis pathway tying it to proteins like ferrochelatase and other enzymes necessary for the iron incorporation into heme. These pathways are essential for managing both cellular iron levels and oxidative stress responses.

Associated diseases and disorders

TRIM10 has associations with conditions like sickle cell disease and anemia. Dysregulation or mutation of TRIM10 can lead to impaired erythroid differentiation or function contributing to these hematologic disorders. Its connection to proteins involved in iron metabolism means that any irregularities may echo into broader heme production issues linking it further to hemolytic diseases.

Product promise

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2 product images

  • Immunocytochemistry/ Immunofluorescence - Anti-TRIM10 antibody (ab151306), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-TRIM10 antibody (ab151306)

    Immunofluorescent analysis of methanol-fixed MCF7 cells labeling TRIM10 with ab151306 antibody at 1/200 dilution. Bottom figure represents cells co-stained with Hoechst 33342.

  • Western blot - Anti-TRIM10 antibody (ab151306), expandable thumbnail

    Western blot - Anti-TRIM10 antibody (ab151306)

    10% SDS PAGE

    All lanes: Western blot - Anti-TRIM10 antibody (ab151306) at 1/1000 dilution

    All lanes: NT2D1 whole cells lysate at 30 µg

    Predicted band size: 55 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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