Rabbit Polyclonal TRIM10 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM10 aa 1-300.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
WB | ICC/IF | |
---|---|---|
Human | Tested | Tested |
Monkey | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Monkey | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Monkey | Dilution info - | Notes - |
E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647).
RFB30, RNF9, TRIM10, RNF9, RFB30, Tripartite motif-containing protein 10, B30-RING finger protein, RING finger protein 9
Rabbit Polyclonal TRIM10 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM10 aa 1-300.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
TRIM10 also known as Tripartite Motif Containing 10 is a protein that belongs to the TRIM family characterized by its tripartite motif which includes a RING finger one or two B-box domains and a coiled-coil region. It has an approximate molecular mass of 60 kDa. TRIM10 expresses mainly in hematopoietic tissues such as the bone marrow and various cell types within the immune system. Its structure suggests a role in protein-protein interactions particularly those involved with ubiquitination processes.
TRIM10 participates in immune response modulation and iron homeostasis. Within biological systems it seems to play a part in a protein complex that influences the cytoskeleton's organization and cellular trafficking. TRIM10 supports erythropoiesis facilitating the maturation and differentiation of erythroid cells in the bone marrow. This involvement highlights its influence in maintaining effective functional condition of red blood cell populations.
TRIM10 participates in the ubiquitin-proteasome pathway which controls the degradation of proteins and is important for regulating protein levels and function in cells. It engages particularly within the heme biosynthesis pathway tying it to proteins like ferrochelatase and other enzymes necessary for the iron incorporation into heme. These pathways are essential for managing both cellular iron levels and oxidative stress responses.
TRIM10 has associations with conditions like sickle cell disease and anemia. Dysregulation or mutation of TRIM10 can lead to impaired erythroid differentiation or function contributing to these hematologic disorders. Its connection to proteins involved in iron metabolism means that any irregularities may echo into broader heme production issues linking it further to hemolytic diseases.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Immunofluorescent analysis of methanol-fixed MCF7 cells labeling TRIM10 with ab151306 antibody at 1/200 dilution. Bottom figure represents cells co-stained with Hoechst 33342.
10% SDS PAGE
All lanes: Western blot - Anti-TRIM10 antibody (ab151306) at 1/1000 dilution
All lanes: NT2D1 whole cells lysate at 30 µg
Predicted band size: 55 kDa
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