AB264190

Anti-TRIM37/MUL antibody

Name: Anti-TRIM37/MUL antibody (ab264190) | Abcam
Brand: Abcam Limited
SKU: AB264190
Price: 525 USD
Availability: InStock

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(7 Publications)

Rabbit Polyclonal TRIM37/MUL antibody. Suitable for IP, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human TRIM37 aa 900 to C-terminus.

View Alternative Names

KIAA0898, MUL, POB1, TRIM37, E3 ubiquitin-protein ligase TRIM37, Mulibrey nanism protein, RING-type E3 ubiquitin transferase TRIM37, Tripartite motif-containing protein 37

2 Images

Supplier Data

Immunoprecipitation - Anti-TRIM37/MUL antibody (AB264190)

TRIM37/MUL was immunoprecipitated from 1 mg HeLa whole cell lysate using ab2641890 at 3 μg/mg lysate. ab264190 was then used for western blotting at 1 μg/ml.

Lane 1 : ab264189 IP in HeLa whole cell lysate.
Lane 2 : ab264190 IP in HeLa whole cell lysate.
Lane 3 : Control IgG.

Detection : Chemiluminescence with an exposure time of 1 second.

All lanes:

Immunoprecipitation - Anti-TRIM37/MUL antibody (ab264190)

Predicted band size: 108 kDa

false

Supplier Data

Western blot - Anti-TRIM37/MUL antibody (AB264190)

All lanes:

Western blot - Anti-TRIM37/MUL antibody (ab264190) at 0.04 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

HeLa whole cell lysate at 5 µg

Lane 4:

HEK-293T whole cell lysate at 50 µg

Predicted band size: 108 kDa

true

Exposure time: 10s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IP

applications

Immunogen

Synthetic Peptide within Human TRIM37 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O94972

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mL", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification

Storage buffer

pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRIM37 also known as MUL is an E3 ubiquitin-protein ligase with a molecular mass of approximately 130 kDa. This protein plays a role in the ubiquitination process which involves labeling proteins for degradation by the proteasome. TRIM37 is widely expressed in various tissues with higher levels seen in the brain liver and heart. The protein contains a RING domain which is important for its ligase activity and mediates the attachment of ubiquitin molecules to substrate proteins therefore controlling the stability and turnover of various cellular proteins.

Biological function summary

TRIM37 regulates processes that are important for cell growth and division as well as for maintaining cellular homeostasis. It functions as part of a larger complex involved in the ubiquitin-proteasome pathway which helps to control protein degradation and recycling within the cell. Through its role in ubiquitination TRIM37 modulates the levels of proteins that are critical for controlling cell cycle progression and responding to stress. Additionally TRIM37 is involved in organizing centrosomes structures that play an important role in chromosome segregation during cell division.

Pathways

TRIM37 interacts with cellular pathways controlling autophagy and the DNA damage response. It contributes to autophagy by regulating proteins that control the formation and clearance of autophagosomes such as ULK1. In the DNA damage response TRIM37 modulates repair processes by regulating the stability of proteins like FANCD2 which is involved in the repair of DNA crosslinks. This illustrates how TRIM37 fits into wider networks inside the cell and influences processes important for maintaining genome integrity.

TRIM37 mutations are linked with Mulibrey nanism a rare growth disorder characterized by multi-organ fibrosis and growth failure. Abnormal functioning of TRIM37 disrupts the regulation of cellular proteins that maintain organ size and structure. Furthermore TRIM37 may play a role in the development of some cancers including breast cancer. In this context the protein can influence cancer progression by modifying the stability of oncogenes or tumor suppressors such as p53 adding further complexity to how TRIM37 impacts disease states.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed : 15885686, PubMed : 23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed : 23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression : associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed : 25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472' : monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed : 28724525). Has anti-HIV activity (PubMed : 24317724).

See full target information TRIM37

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Hereditas 162:47 PubMed40158112

2025

Activation of TRIM37 by ATF6 and degradation of ACSL4: inhibiting ferroptosis and propelling cervical cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Wang,Li Xie,Shiying Jin,YouXiang Hou,Yina Wang

Journal of cancer research and clinical oncology 150:294 PubMed38842683

2024

LncRNA HOXC-AS3 accelerates malignant proliferation of cervical cancer cells via stabilizing KDM5B.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Li,Fang Hou,Zhenghua Teng,Weiwei Xia,Jie Peng

Science advances 10:eadl2036 PubMed38758800

2024

TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Yiyang Qin,Laiqiang Chen,Wenzhen Zhu,Jiahong Song,Jingpan Lin,Yuwei Li,Jiawei Zhang,Xichen Song,Tingting Xing,Tingting Guo,Xuezhi Duan,Yiran Zhang,Eshu Ruan,Qi Wang,Bang Li,Weili Yang,Peng Yin,Xiao-Xin Yan,Shihua Li,Xiao-Jiang Li,Su Yang

Andrology 12:643-654 PubMed37644905

2023

The role of hepatitis B virus surface protein in inducing Sertoli cell ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Chengshuang Pan,Xiangbin Kong,Zhigang Wu,Qianjin Fei

Journal of Cancer 14:200-218 PubMed36741265

2023

Tripartite motif containing 69 elicits ERK2-dependent EYA4 turnover to impart pancreatic tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Jia,Hui-Yan Li,Jue Wang,Xing Chen,Lu Lou,Yan-Yan Wei,Ying Wang,Shi-Jing Mo

Experimental & molecular medicine 54:999-1010 PubMed35859118

2022

PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hanlin Ma,Gonghua Qi,Fang Han,Jiali Peng,Cunzhong Yuan,Beihua Kong

Molecular therapy. Nucleic acids 22:114-123 PubMed32916597

2020

ROS/NF-κB Signaling Pathway-Mediated Transcriptional Activation of TRIM37 Promotes HBV-Associated Hepatic Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Haina Xie,Dongyu Xie,Jingxian Zhang,Wenye Jin,Yue Li,Jun Yao,Zhiqiang Pan,Donghao Xie

View all publications

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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-TRIM37/MUL antibody

Immunoprecipitation - Anti-TRIM37/MUL antibody (AB264190)

Western blot - Anti-TRIM37/MUL antibody (AB264190)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (7)

Product promise