Rabbit Polyclonal TRIM37/MUL antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TRIM37 aa 900 to C-terminus.
View Alternative Names
KIAA0898, MUL, POB1, TRIM37, E3 ubiquitin-protein ligase TRIM37, Mulibrey nanism protein, RING-type E3 ubiquitin transferase TRIM37, Tripartite motif-containing protein 37
- IP
Supplier Data
Immunoprecipitation - Anti-TRIM37/MUL antibody (AB264190)
TRIM37/MUL was immunoprecipitated from 1 mg HeLa whole cell lysate using ab2641890 at 3 μg/mg lysate. ab264190 was then used for western blotting at 1 μg/ml.
Lane 1 : ab264189 IP in HeLa whole cell lysate.
Lane 2 : ab264190 IP in HeLa whole cell lysate.
Lane 3 : Control IgG.
Detection : Chemiluminescence with an exposure time of 1 second.
All lanes:
Immunoprecipitation - Anti-TRIM37/MUL antibody (ab264190)
Predicted band size: 108 kDa
false
- WB
Supplier Data
Western blot - Anti-TRIM37/MUL antibody (AB264190)
All lanes:
Western blot - Anti-TRIM37/MUL antibody (ab264190) at 0.04 µg/mL
Lane 1:
HeLa whole cell lysate at 50 µg
Lane 2:
HeLa whole cell lysate at 15 µg
Lane 3:
HeLa whole cell lysate at 5 µg
Lane 4:
HEK-293T whole cell lysate at 50 µg
Predicted band size: 108 kDa
true
Exposure time: 10s
Reactivity data
Properties and storage information
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Purification technique
Storage buffer
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Appropriate long-term storage conditions
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Storage information
Supplementary information
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Biological function summary
TRIM37 regulates processes that are important for cell growth and division as well as for maintaining cellular homeostasis. It functions as part of a larger complex involved in the ubiquitin-proteasome pathway which helps to control protein degradation and recycling within the cell. Through its role in ubiquitination TRIM37 modulates the levels of proteins that are critical for controlling cell cycle progression and responding to stress. Additionally TRIM37 is involved in organizing centrosomes structures that play an important role in chromosome segregation during cell division.
Pathways
TRIM37 interacts with cellular pathways controlling autophagy and the DNA damage response. It contributes to autophagy by regulating proteins that control the formation and clearance of autophagosomes such as ULK1. In the DNA damage response TRIM37 modulates repair processes by regulating the stability of proteins like FANCD2 which is involved in the repair of DNA crosslinks. This illustrates how TRIM37 fits into wider networks inside the cell and influences processes important for maintaining genome integrity.
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Target data
Publications (2)
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Journal of Cancer 14:200-218 PubMed36741265
2023
Applications
Unspecified application
Species
Unspecified reactive species
Molecular therapy. Nucleic acids 22:114-123 PubMed32916597
2020
Applications
Unspecified application
Species
Unspecified reactive species
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