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AB254941

Anti-TRIM46 antibody

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(1 Publication)

Rabbit Polyclonal TRIM46 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM46 aa 450-600.

View Alternative Names

TRIFIC, TRIM46, Tripartite motif-containing protein 46, Gene Y protein, GeneY

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM46 antibody (AB254941)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM46 antibody (AB254941)

Paraffin-embedded human cerebral cortex tissue stained for TRIM46 using ab254941 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM46 antibody (AB254941)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM46 antibody (AB254941)

Paraffin-embedded human liver tissue stained for TRIM46 using ab254941 at 1/200 dilution in immunohistochemical analysis. Low expression as expected.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TRIM46 aa 450-600. The exact immunogen used to generate this antibody is proprietary information.

Q7Z4K8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRIM46 also known as Tripartite Motif Containing 46 functions as a microtubule-organizing protein in the nervous system. It weighs approximately 82 kDa. This protein plays a role in stabilizing the microtubule network and is expressed mainly in neuronal cells and tissues. TRIM46 supports axon initiation and proper neuronal polarity by anchoring microtubules contributing to the organization of the axon initial segment.
Biological function summary

TRIM46 is involved in the regulation of microtubule dynamics. It associates with microtubule-associated proteins to promote stability and organization within neurons. Although not known to be part of a large complex TRIM46 interacts with proteins like EB1 to facilitate microtubule bundle formation. These interactions are important for axon guidance and neural signaling.

Pathways

TRIM46 participates in axon guidance and neural development pathways. It engages with the MAP kinase signaling pathway influencing cellular responses to growth factors. Additionally it relates to the Wnt signaling pathway where it's connected with proteins such as Dishevelled and β-catenin impacting neural patterning and development.

Deficiencies in TRIM46 have links to neurodevelopmental disorders and neurodegenerative diseases. Alterations in TRIM46 expression associate with autism spectrum disorders affecting neural connectivity and signaling. The protein also connects with Tau a protein implicated in Alzheimer's disease suggesting a role in microtubule-related neuronal dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.
See full target information TRIM46
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Publications (1)

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Cell death & disease 16:564 PubMed40715045

2025

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Applications

Unspecified application

Species

Unspecified reactive species

Li Yang,Xiaoqin An,Shangzhu Yang,Xiaowen Lin,Ziyuan Chen,Qian Xue,Xi Chen,Yuan Wang,Ding Yan,Shirui Chen,Yuqing Fan,Daolin Tang,Wenfeng Yu,Jinbao Liu,Xin Chen
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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