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AB229152

Anti-TRIM49 antibody

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(1 Publication)

Rabbit Polyclonal TRIM49 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM49.

View Alternative Names

RNF18, TRIM49, Tripartite motif-containing protein 49, RING finger protein 18, Testis-specific RING-finger protein

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM49 antibody (AB229152)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM49 antibody (AB229152)

Paraffin-embedded TOV-21G xenograft stained for TRIM49 using ab229152 at 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-TRIM49 antibody (AB229152)
  • WB

Supplier Data

Western blot - Anti-TRIM49 antibody (AB229152)

10% SDS-PAGE

All lanes:

Western blot - Anti-TRIM49 antibody (ab229152) at 1/1000 dilution

All lanes:

NT2D1 whole cell lysate at 30 µg

Predicted band size: 52 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TRIM49. The exact immunogen used to generate this antibody is proprietary information.

P0CI25

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRIM49 also known as Tripartite Motif Containing 49 is a member of the TRIM protein family. It functions mechanically as an E3 ubiquitin ligase facilitating ubiquitination processes. TRIM49 has a molecular mass of approximately 55 kDa. This protein is expressed mainly in the testis indicating its significance in reproductive biology.
Biological function summary

TRIM49 plays a role in protein modification and turnover by marking specific substrates for degradation via the ubiquitin-proteasome system. It is not currently known to be part of a larger protein complex but its activity influences cellular regulation and protein homeostasis.

Pathways

Studies suggest that TRIM49 engages in the regulation of immune response and cell cycle control pathways. It interacts with proteins involved in these pathways including IFN-signaling pathways where it has potential effects on proteins like STAT1 modulating cellular responses to cytokines.

TRIM49's function connects it to testicular cancers and other reproductive disorders. Variations in TRIM49 expression or function may associate with abnormal testicular cell proliferation. Interaction with proteins like p53 an important tumor suppressor highlights its link to mechanisms of cancer development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TRIM49
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 18:4421-4428 PubMed31611951

2019

STAMBPL1 knockdown has antitumour effects on gastric cancer biological activities.

Applications

Unspecified application

Species

Unspecified reactive species

Da-Jun Yu,Jun Qian,Xin Jin,Jing Li,Chen-Xu Guo,Xi-Cheng Yue
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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