Anti-TRIM8 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TRIM8 also known as Tripartite Motif Containing 8 is an E3 ubiquitin ligase with a known mass of about 61 kDa. This protein facilitates protein degradation via the ubiquitin-proteasome system. It localizes to the nucleus and cytoplasm and is expressed in various tissues such as the brain and immune cells. TRIM8 influences multiple cellular processes by adding ubiquitin chains to specific proteins thereby tagging them for degradation.

Biological function summary

TRIM8 is involved in the regulation of signaling pathways and acts as a modulator of cellular functions. TRIM8 participates in the stability and turnover of p53 and STAT3 affecting their transcriptional activities. It also contributes to immune responses by modulating pathways that involve interferon signaling. TRIM8 is not typically part of large protein complexes; its interactions often involve single protein-protein connections.

Pathways

TRIM8 plays significant roles in immune signaling and apoptosis regulation. It interacts with the NF-kB pathway influencing inflammation and immune responses. Through this pathway TRIM8 impacts the activation of transcriptional activity affecting cellular survival and proliferation. Additionally TRIM8 interacts with proteins like p53 altering its function in the apoptotic pathway thereby influencing cell cycle regulation and survival.

Associated diseases and disorders

TRIM8 has connections to cancer and neurodegenerative diseases. For cancer abnormalities in TRIM8 expression levels can result in altered p53 activity promoting tumor growth or suppression. In neurodegenerative contexts TRIM8's interaction with STAT3 can affect inflammatory responses linked to diseases like Alzheimer's. These relationships highlight the importance of TRIM8 in both the progression and inhibition of certain pathologies through its interactions with proteins such as p53 and STAT3.