Anti-TRIML1 antibody [EPR12520] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TRIML1 also known as Tripartite Motif Containing Like 1 is a protein involved in E3 ubiquitin ligase activity. The protein promotes ubiquitination by attaching ubiquitin molecules to substrate proteins tagging them for various cellular fates. TRIML1 weighs approximately 74 kDa and it is expressed in various tissues including immune cells and specific brain regions. The protein’s modular structure consists of a RING finger domain B-boxes and a coiled-coil region which aids in its regulatory functions.

Biological function summary

The protein plays a role in immune response regulation and maintaining protein homeostasis. TRIML1 does not exist as part of a large complex but interacts directly with specific substrates and signaling molecules. The RING finger domain facilitates its binding to E2 ubiquitin-conjugating enzyme enhancing its function in protein degradation and signal transduction. Furthermore TRIML1 modulates inflammation by its action on pro-inflammatory signaling pathways.

Pathways

TRIML1 is engaged mainly in the ubiquitin-proteasome system and the inflammatory signaling pathways. In the context of the ubiquitin-proteasome system TRIML1 influences protein turnover and cellular responses to stress. Additionally it participates in the regulation of NF-kB signaling which is essential for inflammatory responses. Its interactions with proteins such as UBE2D serve as critical connections in these pathways assisting in both protein ubiquitination and inflammatory regulation.

Associated diseases and disorders

TRIML1 shows connections particularly to neurodegenerative diseases and certain immune disorders. Alterations in TRIML1 expression or function can contribute to proteostasis imbalances implicated in disorders such as Alzheimer's disease. The protein's influence on inflammatory pathways suggests a potential role in autoimmune conditions. In these contexts proteins like NF-kB become highly relevant as both TRIML1 and NF-kB coordinate immune signaling which can exacerbate or mitigate disease development.